A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

Seulki Lee; Eui Joon Cha; Kyeongsoon Park; Seung Young Lee; Jin Ki Hong; In Cheol Sun; Sang Yoon Kim; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1002/anie.200705240

A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

Seulki Lee
, Eui Joon Cha
, Kyeongsoon Park
, Seung Young Lee
, Jin Ki Hong
, In Cheol Sun
, Sang Yoon Kim
, Kuiwon Choi
, Ick Chan Kwon
, Kwangmeyung Kim
, Cheol Hee Ahn

Research output: Contribution to journal › Article › peer-review

271 Scopus citations

Abstract

(Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).

Original language	English (US)
Pages (from-to)	2804-2807
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	15
DOIs	https://doi.org/10.1002/anie.200705240
State	Published - Mar 31 2008
Externally published	Yes

Keywords

Cancer diagnosis
Drug screening
Fluorescent probes
Gold
Imaging agents

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200705240

Cite this

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title = "A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination",

abstract = "(Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).",

keywords = "Cancer diagnosis, Drug screening, Fluorescent probes, Gold, Imaging agents",

author = "Seulki Lee and Cha, \{Eui Joon\} and Kyeongsoon Park and Lee, \{Seung Young\} and Hong, \{Jin Ki\} and Sun, \{In Cheol\} and Kim, \{Sang Yoon\} and Kuiwon Choi and Kwon, \{Ick Chan\} and Kwangmeyung Kim and Ahn, \{Cheol Hee\}",

year = "2008",

month = mar,

day = "31",

doi = "10.1002/anie.200705240",

language = "English (US)",

volume = "47",

pages = "2804--2807",

journal = "Angewandte Chemie - International Edition",

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publisher = "John Wiley and Sons Ltd",

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TY - JOUR

T1 - A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

AU - Lee, Seulki

AU - Cha, Eui Joon

AU - Park, Kyeongsoon

AU - Lee, Seung Young

AU - Hong, Jin Ki

AU - Sun, In Cheol

AU - Kim, Sang Yoon

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2008/3/31

Y1 - 2008/3/31

N2 - (Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).

AB - (Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).

KW - Cancer diagnosis

KW - Drug screening

KW - Fluorescent probes

KW - Gold

KW - Imaging agents

UR - https://www.scopus.com/pages/publications/42249084437

UR - https://www.scopus.com/pages/publications/42249084437#tab=citedBy

U2 - 10.1002/anie.200705240

DO - 10.1002/anie.200705240

M3 - Article

C2 - 18306196

AN - SCOPUS:42249084437

SN - 1433-7851

VL - 47

SP - 2804

EP - 2807

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 15

ER -

A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

Abstract

Keywords

ASJC Scopus subject areas

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