A near-infrared fluorescence-based optical thermosensor

Seung Young Lee; Seulki Lee; In Chan Youn; Dong Kee Yi; Yong Taik Lim; Bong Hyun Chung; James F. Leary; Ick Chan Kwon; Kwangmeyung Kim; Kuiwon Choi

doi:10.1002/chem.200900683

A near-infrared fluorescence-based optical thermosensor

Seung Young Lee, Seulki Lee, In Chan Youn, Dong Kee Yi, Yong Taik Lim, Bong Hyun Chung, James F. Leary, Ick Chan Kwon, Kwangmeyung Kim, Kuiwon Choi

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A study was conducted to demonstrate the development of a fluorescent polymeric thermosensor, exhibiting selective near-infrared (NIR) emission throughout a broad range of temperatures based on the fluorescent signal activation method. The NIR fluorescent thermosensor had the advantage to be applied in biological and medical field, as it was possible to image tissues at different resolutions and depth penetrations in minimizing tissue autofluorescence in NIR region. The thermosensor was designed using a combination of thermo-responsive polymer and an NIR dye, Pluronic F127, and Cy5.5. It was demonstrated that it was possible to synthesize a thermosensor for monitoring specific temperature range by using proper block copolymers. It was also demonstrated that the sensitive quenching properties of polymeric sensors allowed to monitor temperature changes by observing changes in NIR emission intensity and by visualized fluorescent images.

Original language	English (US)
Pages (from-to)	6103-6106
Number of pages	4
Journal	Chemistry - A European Journal
Volume	15
Issue number	25
DOIs	https://doi.org/10.1002/chem.200900683
State	Published - Jun 15 2009
Externally published	Yes

Keywords

Aggregation
Imaging agents
Micelles
Sensors

ASJC Scopus subject areas

General Chemistry
Catalysis
Organic Chemistry

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10.1002/chem.200900683

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title = "A near-infrared fluorescence-based optical thermosensor",

abstract = "A study was conducted to demonstrate the development of a fluorescent polymeric thermosensor, exhibiting selective near-infrared (NIR) emission throughout a broad range of temperatures based on the fluorescent signal activation method. The NIR fluorescent thermosensor had the advantage to be applied in biological and medical field, as it was possible to image tissues at different resolutions and depth penetrations in minimizing tissue autofluorescence in NIR region. The thermosensor was designed using a combination of thermo-responsive polymer and an NIR dye, Pluronic F127, and Cy5.5. It was demonstrated that it was possible to synthesize a thermosensor for monitoring specific temperature range by using proper block copolymers. It was also demonstrated that the sensitive quenching properties of polymeric sensors allowed to monitor temperature changes by observing changes in NIR emission intensity and by visualized fluorescent images.",

keywords = "Aggregation, Imaging agents, Micelles, Sensors",

author = "Lee, {Seung Young} and Seulki Lee and Youn, {In Chan} and Yi, {Dong Kee} and Lim, {Yong Taik} and Chung, {Bong Hyun} and Leary, {James F.} and Kwon, {Ick Chan} and Kwangmeyung Kim and Kuiwon Choi",

year = "2009",

month = jun,

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doi = "10.1002/chem.200900683",

language = "English (US)",

volume = "15",

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AU - Lee, Seung Young

AU - Lee, Seulki

AU - Youn, In Chan

AU - Yi, Dong Kee

AU - Lim, Yong Taik

AU - Chung, Bong Hyun

AU - Leary, James F.

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Choi, Kuiwon

PY - 2009/6/15

Y1 - 2009/6/15

N2 - A study was conducted to demonstrate the development of a fluorescent polymeric thermosensor, exhibiting selective near-infrared (NIR) emission throughout a broad range of temperatures based on the fluorescent signal activation method. The NIR fluorescent thermosensor had the advantage to be applied in biological and medical field, as it was possible to image tissues at different resolutions and depth penetrations in minimizing tissue autofluorescence in NIR region. The thermosensor was designed using a combination of thermo-responsive polymer and an NIR dye, Pluronic F127, and Cy5.5. It was demonstrated that it was possible to synthesize a thermosensor for monitoring specific temperature range by using proper block copolymers. It was also demonstrated that the sensitive quenching properties of polymeric sensors allowed to monitor temperature changes by observing changes in NIR emission intensity and by visualized fluorescent images.

AB - A study was conducted to demonstrate the development of a fluorescent polymeric thermosensor, exhibiting selective near-infrared (NIR) emission throughout a broad range of temperatures based on the fluorescent signal activation method. The NIR fluorescent thermosensor had the advantage to be applied in biological and medical field, as it was possible to image tissues at different resolutions and depth penetrations in minimizing tissue autofluorescence in NIR region. The thermosensor was designed using a combination of thermo-responsive polymer and an NIR dye, Pluronic F127, and Cy5.5. It was demonstrated that it was possible to synthesize a thermosensor for monitoring specific temperature range by using proper block copolymers. It was also demonstrated that the sensitive quenching properties of polymeric sensors allowed to monitor temperature changes by observing changes in NIR emission intensity and by visualized fluorescent images.

KW - Aggregation

KW - Imaging agents

KW - Micelles

KW - Sensors

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ER -

A near-infrared fluorescence-based optical thermosensor

Abstract

Keywords

ASJC Scopus subject areas

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