A Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine

Agriculture & Biology

• sigma factors 81%
• Mycobacterium tuberculosis 76%
• regulon 29%
• cells 20%
• tuberculosis 18%
• transporters 13%
• therapeutics 12%
• drugs 10%
• drug development 10%
• gene expression 9%
• fatty acid metabolism 9%
• aerobiosis 8%
• drug therapy 7%
• operon 7%
• membrane proteins 7%
• electron microscopy 6%
• stress response 6%
• pathogens 4%
• mutants 4%
• enzymes 3%
• genes 2%
• methodology 2%

Medicine & Life Sciences

• Thioridazine 93%
• Sigma Factor 85%
• Mycobacterium tuberculosis 62%
• Regulon 22%
• Extensively Drug-Resistant Tuberculosis 8%
• Operon 6%
• Combination Drug Therapy 5%
• Drug Development 5%
• Transcriptome 5%
• Oxidoreductases 5%
• Electron Microscopy 4%
• Fatty Acids 4%
• Membrane Proteins 4%
• Respiration 4%
• Tuberculosis 4%
• Therapeutics 3%
• Gene Expression 3%
• Enzymes 3%
• Pharmaceutical Preparations 2%
• Genes 2%

Chemical Compounds

• Thioridazine 100%
• Pump 5%
• Electron Microscopy 5%
• Fatty Acid 4%
• Pharmacological Metabolism 4%
• Drug 3%
• Protein 2%