A multivariate analysis of risk factors for hepatitis b virus infection among hospital employees screened for vaccination

David R. Snydman, Alvaro Munoz, Barbara G. Werner, B. Frank Polk, Donald E. Craven, Richard Platt, Clyde Crumpacker, Rita Ouellet-hellstrom, Barbara Nash, George F. Grady, Jules L. Dienstag

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Previous studies of risk factors for hepatitis B virus infection among hospital employees have been based on surveys in single institutions or have been analyzed with univariate techniques. From November 1980 through August 1981, the authors performed a multi-institutional seroepidemiologic survey of hospital employees screened for entrance into a hepatatis B vaccine trial who represented groups at high risk for hepatitis B Infection. Using a logistic regression model for the analysis of risk factors, the investigators determined the relative odds and 95% confidence intervals for risk of hepatitis B infection to be as follows: race (nonwhite/white: 3.4; 2.4-4.8) (p < 0.001); history of acute viral hepatitis of an unspecified type (3.6; 2.2-5.9) (p < 0.001); and employment at hospitals 1 through 5 as compared with hospital 6 (1.8; 1.1-2.9) (p = 0.015). In addition, certain job categories and the duration of employment within some of these categories were associated with increasing risk for hepatitis B infection over time. Laboratory workers (1.4; 1.2-1.7), surgical staff (1.2; 1.1-1.4), and medical staff (1.3; 1.1-1.5) had significant (p < 0.05) increased risk of prior infection with longer duration of employment. Such time-job interaction was not demonstrable for nursing staff, anesthesiology staff, dental personnel, pathology staff, or ancillary personnel. The logistic regression model also shows that the highest gradient of risk for laboratory workers, surgeons, and medical staff occurs during the first five years of employment. An effective preventive strategy, such as the use of hepatitis B vaccine, should be targeted for these groups at the time of initial employment.

Original languageEnglish (US)
Pages (from-to)684-693
Number of pages10
JournalAmerican journal of epidemiology
Issue number5
StatePublished - Nov 1984
Externally publishedYes


  • Hepatitis B
  • Hospital
  • Immunization
  • Occupational diseases
  • Personnel

ASJC Scopus subject areas

  • Epidemiology


Dive into the research topics of 'A multivariate analysis of risk factors for hepatitis b virus infection among hospital employees screened for vaccination'. Together they form a unique fingerprint.

Cite this