A multicentre, prospective, randomized, controlled trial comparing EVARREST™ fibrin sealant patch to standard of care in controlling bleeding following elective hepatectomy: anatomic versus non-anatomic resection

Jonathan B. Koea; Jonathan Batiller; Nicolas Aguirre; Jessica Shen; Richard Kocharian; Grant Bochicchio; O. James Garden

doi:10.1016/j.hpb.2015.12.006

A multicentre, prospective, randomized, controlled trial comparing EVARREST™ fibrin sealant patch to standard of care in controlling bleeding following elective hepatectomy: anatomic versus non-anatomic resection

Jonathan B. Koea, Jonathan Batiller, Nicolas Aguirre, Jessica Shen, Richard Kocharian, Grant Bochicchio, O. James Garden

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background This multicentre, randomized clinical trial assessed the safety and effectiveness of the EVARREST™ Fibrin Sealant Patch (FP) in treating parenchymal bleeding following anatomic and non-anatomic liver resections. Methods One hundred and two patients were stratified according to the type of hepatic resection (anatomic/non-anatomic), and randomized (1:1) after identification of an appropriate bleeding site, to FP vs Standard of Care (SoC, manual compression ± topical haemostat). The primary endpoint was haemostasis at 4 min from bleeding site identification with no re-bleeding requiring re-treatment. Results The FP was superior in achieving haemostasis at 4 min (96%, 48/50) to SoC (46%, 24/52; p

Original language	English (US)
Pages (from-to)	221-228
Number of pages	8
Journal	HPB
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.hpb.2015.12.006
State	Published - 2016
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology
Hepatology

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Koea, J. B., Batiller, J., Aguirre, N., Shen, J., Kocharian, R., Bochicchio, G., & Garden, O. J. (2016). A multicentre, prospective, randomized, controlled trial comparing EVARREST™ fibrin sealant patch to standard of care in controlling bleeding following elective hepatectomy: anatomic versus non-anatomic resection. HPB, 18(3), 221-228. https://doi.org/10.1016/j.hpb.2015.12.006

A multicentre, prospective, randomized, controlled trial comparing EVARREST™ fibrin sealant patch to standard of care in controlling bleeding following elective hepatectomy: anatomic versus non-anatomic resection. / Koea, Jonathan B.; Batiller, Jonathan; Aguirre, Nicolas et al.
In: HPB, Vol. 18, No. 3, 2016, p. 221-228.

Research output: Contribution to journal › Article › peer-review

Koea, JB, Batiller, J, Aguirre, N, Shen, J, Kocharian, R, Bochicchio, G & Garden, OJ 2016, 'A multicentre, prospective, randomized, controlled trial comparing EVARREST™ fibrin sealant patch to standard of care in controlling bleeding following elective hepatectomy: anatomic versus non-anatomic resection', HPB, vol. 18, no. 3, pp. 221-228. https://doi.org/10.1016/j.hpb.2015.12.006

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abstract = "Background This multicentre, randomized clinical trial assessed the safety and effectiveness of the EVARREST{\texttrademark} Fibrin Sealant Patch (FP) in treating parenchymal bleeding following anatomic and non-anatomic liver resections. Methods One hundred and two patients were stratified according to the type of hepatic resection (anatomic/non-anatomic), and randomized (1:1) after identification of an appropriate bleeding site, to FP vs Standard of Care (SoC, manual compression ± topical haemostat). The primary endpoint was haemostasis at 4 min from bleeding site identification with no re-bleeding requiring re-treatment. Results The FP was superior in achieving haemostasis at 4 min (96%, 48/50) to SoC (46%, 24/52; p ",

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doi = "10.1016/j.hpb.2015.12.006",

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AU - Koea, Jonathan B.

AU - Batiller, Jonathan

AU - Aguirre, Nicolas

AU - Shen, Jessica

AU - Kocharian, Richard

AU - Bochicchio, Grant

AU - Garden, O. James

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AB - Background This multicentre, randomized clinical trial assessed the safety and effectiveness of the EVARREST™ Fibrin Sealant Patch (FP) in treating parenchymal bleeding following anatomic and non-anatomic liver resections. Methods One hundred and two patients were stratified according to the type of hepatic resection (anatomic/non-anatomic), and randomized (1:1) after identification of an appropriate bleeding site, to FP vs Standard of Care (SoC, manual compression ± topical haemostat). The primary endpoint was haemostasis at 4 min from bleeding site identification with no re-bleeding requiring re-treatment. Results The FP was superior in achieving haemostasis at 4 min (96%, 48/50) to SoC (46%, 24/52; p

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A multicentre, prospective, randomized, controlled trial comparing EVARREST™ fibrin sealant patch to standard of care in controlling bleeding following elective hepatectomy: anatomic versus non-anatomic resection

Abstract

ASJC Scopus subject areas

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