A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia

Ned Sacktor, Richard L. Skolasky, Thomas Ernst, Xiangling Mao, Ola Selnes, Martin G. Pomper, Linda Chang, Kai Zhong, Dikoma C. Shungu, Karen Marder, Dean Shibata, Giovanni Schifitto, Linda Bobo, Peter B. Barker, D. Phil

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Purpose: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. Materials and Methods: Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. Results: HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. Conclusion: SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures ml, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Issue number4
StatePublished - Apr 2005


  • Dementia
  • HIV
  • Magnetic resonance spectroscopy
  • Multicenter
  • Technique

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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