TY - JOUR
T1 - A multicenter investigation examining timing of penile prosthesis infection management and responsible organisms
AU - Rezaee, Michael E.
AU - Swanton, Amanda R.
AU - Gross, Martin S.
AU - Munarriz, Ricardo M.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022
Y1 - 2022
N2 - The purpose of this investigation was to examine the timing of penile prosthesis infection management by different responsible organisms. A retrospective cohort study was performed of patients who underwent penile prosthesis salvage or explant procedures due to a suspected infection between 2001 and 2018. The cohort consisted of 216 patients from 33 different facilities and six countries. The most common primary organisms responsible for device infections included, Gram-positives (31.5%), no growth cultures (30.6%), Gram-negatives (22.2%), fungal (11.6%), and anaerobic organisms (4.2%). Overall, median time to infection was 1.8 (interquartile range [IQR]: 1.0–3.0) months for all patients. Median time to infection management was similar between responsible organisms: 1.0 (IQR: 1.0–2.3) months for Gram-negatives and 2 months for Gram-positives (IQR: 1.0–1.4), fungal (IQR: 1.0–5.0), anaerobes (IQR: 1.0–2.5), and no growth cultures (IQR: 1.0–3.0, p = 0.56). Median time to infection management was significantly shorter among patients who received aminoglycoside/vancomycin prophylaxis (1.5 months, IQR: 1.0–2.5, p < 0.01) compared to other antibiotic groups. Median time to infection management was significantly longer for patients managed with a three-piece inflatable implant salvage procedure (2.8 months, IQR: 1.0–5.0, p = 0.02) compared to other salvage procedures. Conventional wisdom surrounding early versus late penile prosthesis infections should largely be abandoned. More than half of penile prosthesis infections are surgically managed within 2 months of initial device placement.
AB - The purpose of this investigation was to examine the timing of penile prosthesis infection management by different responsible organisms. A retrospective cohort study was performed of patients who underwent penile prosthesis salvage or explant procedures due to a suspected infection between 2001 and 2018. The cohort consisted of 216 patients from 33 different facilities and six countries. The most common primary organisms responsible for device infections included, Gram-positives (31.5%), no growth cultures (30.6%), Gram-negatives (22.2%), fungal (11.6%), and anaerobic organisms (4.2%). Overall, median time to infection was 1.8 (interquartile range [IQR]: 1.0–3.0) months for all patients. Median time to infection management was similar between responsible organisms: 1.0 (IQR: 1.0–2.3) months for Gram-negatives and 2 months for Gram-positives (IQR: 1.0–1.4), fungal (IQR: 1.0–5.0), anaerobes (IQR: 1.0–2.5), and no growth cultures (IQR: 1.0–3.0, p = 0.56). Median time to infection management was significantly shorter among patients who received aminoglycoside/vancomycin prophylaxis (1.5 months, IQR: 1.0–2.5, p < 0.01) compared to other antibiotic groups. Median time to infection management was significantly longer for patients managed with a three-piece inflatable implant salvage procedure (2.8 months, IQR: 1.0–5.0, p = 0.02) compared to other salvage procedures. Conventional wisdom surrounding early versus late penile prosthesis infections should largely be abandoned. More than half of penile prosthesis infections are surgically managed within 2 months of initial device placement.
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U2 - 10.1038/s41443-022-00659-0
DO - 10.1038/s41443-022-00659-0
M3 - Article
C2 - 36564583
AN - SCOPUS:85144670612
SN - 0955-9930
JO - International Journal of Impotence Research
JF - International Journal of Impotence Research
ER -