A multi-scanner study of subcortical brain volume abnormalities in schizophrenia

Theo G.M. Van Erp, Douglas N. Greve, Jerod Rasmussen, Jessica Turner, Vince D. Calhoun, Sarah Young, Bryon Mueller, Gregory G. Brown, Gregory McCarthy, Gary H. Glover, Kelvin O. Lim, Juan R. Bustillo, Aysenil Belger, Sarah McEwen, James Voyvodic, Daniel H. Mathalon, David Keator, Adrian Preda, Dana Nguyen, Judith M. FordSteven G. Potkin

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Schizophrenia patients show significant subcortical brain abnormalities. We examined these abnormalities using automated image analysis software and provide effect size estimates for prospective multi-scanner schizophrenia studies. Subcortical and intracranial volumes were obtained using FreeSurfer 5.0.0 from high-resolution structural imaging scans from 186 schizophrenia patients (mean age±S.D.=38.9±11.6, 78% males) and 176 demographically similar controls (mean age±S.D.=37.5±11.2, 72% males). Scans were acquired from seven 3-Tesla scanners. Univariate mixed model regression analyses compared between-group volume differences. Weighted mean effect sizes (and number of subjects needed for 80% power at α=0.05) were computed based on the individual single site studies as well as on the overall multi-site study. Schizophrenia patients have significantly smaller intracranial, amygdala, and hippocampus volumes and larger lateral ventricle, putamen and pallidum volumes compared with healthy volunteers. Weighted mean effect sizes based on single site studies were generally larger than effect sizes computed based on analysis of the overall multi-site sample. Prospectively collected structural imaging data can be combined across sites to increase statistical power for meaningful group comparisons. Even when using similar scan protocols at each scanner, some between-site variance remains. The multi-scanner effect sizes provided by this study should help in the design of future multi-scanner schizophrenia imaging studies.

Original languageEnglish (US)
Pages (from-to)10-16
Number of pages7
JournalPsychiatry Research - Neuroimaging
Issue number1-2
StatePublished - Apr 30 2014
Externally publishedYes


  • Effect size
  • Imaging
  • Magnetic resonance imaging (MRI)
  • Psychosis

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


Dive into the research topics of 'A multi-scanner study of subcortical brain volume abnormalities in schizophrenia'. Together they form a unique fingerprint.

Cite this