A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity

Erick A. Perez-Alday; Haibo Ni; Christopher Hamilton; Annabel Li-Pershing; Bernard Jaar; Jose M. Monroy-Trujillo; Michelle Estrella; Rulan Parekh; Henggui Zhang; Larisa Tereshchenko

doi:10.22489/CinC.2018.161

A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity

Erick A. Perez-Alday, Haibo Ni, Christopher Hamilton, Annabel Li-Pershing, Bernard Jaar, Jose M. Monroy-Trujillo, Michelle Estrella, Rulan Parekh, Henggui Zhang, Larisa Tereshchenko

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Extracardiac factors such as respiration, fluid overload and body habitus have important effects on the ECG voltage. Vectorcardiographic (VCG) Global Electrical Heterogeneity (GEH) is associated with sudden cardiac death (SCD). Risk of SCD is especially high in end-stage renal disease patients (ESRD) on dialysis. However, extracardiac factors challenge ECG interpretation in ESRD patients. The effects of extracardiac factors on GEH have not been fully studied. To assess effects of extracardiac factors on ECG, we conducted a multi-scale study. An experimental data of ESRD patients and a previously developed biophysically detailed heart-torso model were used to investigate the effects of respiration, fluid overload and body habitus on the VCG and GEH.

Original language	English (US)
Title of host publication	Computing in Cardiology Conference, CinC 2018
Publisher	IEEE Computer Society
ISBN (Electronic)	9781728109589
DOIs	https://doi.org/10.22489/CinC.2018.161
State	Published - Sep 2018
Event	45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Netherlands Duration: Sep 23 2018 → Sep 26 2018

Publication series

Name	Computing in Cardiology
Volume	2018-September
ISSN (Print)	2325-8861
ISSN (Electronic)	2325-887X

Conference

Conference	45th Computing in Cardiology Conference, CinC 2018
Country/Territory	Netherlands
City	Maastricht
Period	9/23/18 → 9/26/18

ASJC Scopus subject areas

General Computer Science
Cardiology and Cardiovascular Medicine

Access to Document

10.22489/CinC.2018.161

Cite this

Perez-Alday, E. A., Ni, H., Hamilton, C., Li-Pershing, A., Jaar, B., Monroy-Trujillo, J. M., Estrella, M., Parekh, R., Zhang, H., & Tereshchenko, L. (2018). A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity. In Computing in Cardiology Conference, CinC 2018 Article 8743829 (Computing in Cardiology; Vol. 2018-September). IEEE Computer Society. https://doi.org/10.22489/CinC.2018.161

A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity. / Perez-Alday, Erick A.; Ni, Haibo; Hamilton, Christopher et al.
Computing in Cardiology Conference, CinC 2018. IEEE Computer Society, 2018. 8743829 (Computing in Cardiology; Vol. 2018-September).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Perez-Alday, EA, Ni, H, Hamilton, C, Li-Pershing, A, Jaar, B , Monroy-Trujillo, JM, Estrella, M, Parekh, R, Zhang, H & Tereshchenko, L 2018, A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity. in Computing in Cardiology Conference, CinC 2018., 8743829, Computing in Cardiology, vol. 2018-September, IEEE Computer Society, 45th Computing in Cardiology Conference, CinC 2018, Maastricht, Netherlands, 9/23/18. https://doi.org/10.22489/CinC.2018.161

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abstract = "Extracardiac factors such as respiration, fluid overload and body habitus have important effects on the ECG voltage. Vectorcardiographic (VCG) Global Electrical Heterogeneity (GEH) is associated with sudden cardiac death (SCD). Risk of SCD is especially high in end-stage renal disease patients (ESRD) on dialysis. However, extracardiac factors challenge ECG interpretation in ESRD patients. The effects of extracardiac factors on GEH have not been fully studied. To assess effects of extracardiac factors on ECG, we conducted a multi-scale study. An experimental data of ESRD patients and a previously developed biophysically detailed heart-torso model were used to investigate the effects of respiration, fluid overload and body habitus on the VCG and GEH.",

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AB - Extracardiac factors such as respiration, fluid overload and body habitus have important effects on the ECG voltage. Vectorcardiographic (VCG) Global Electrical Heterogeneity (GEH) is associated with sudden cardiac death (SCD). Risk of SCD is especially high in end-stage renal disease patients (ESRD) on dialysis. However, extracardiac factors challenge ECG interpretation in ESRD patients. The effects of extracardiac factors on GEH have not been fully studied. To assess effects of extracardiac factors on ECG, we conducted a multi-scale study. An experimental data of ESRD patients and a previously developed biophysically detailed heart-torso model were used to investigate the effects of respiration, fluid overload and body habitus on the VCG and GEH.

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A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity

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