A Multi-Center Analysis Evaluating Factors Associated with Spinal Cord Stimulation Outcome in Chronic Pain Patients

Kayode A. Williams, Marlis Gonzalez-Fernandez, Sayeh Hamzehzadeh, Indy Wilkinson, Michael A. Erdek, Anthony Plunkett, Scott Griffith, Matthew Crooks, Thomas Larkin, Steven P. Cohen

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Background. In addition to its conventional use as a treatment for refractory neuropathic extremity pain, spinal cord stimulation (SCS) has recently emerged as a possible treatment for visceral and arthritic pain. But concurrent with the expansion of possible conditions amenable to SCS, other studies have questioned the long-term efficacy of SCS for traditional indications. These disparate findings argue strongly for the refinement of selection criteria. The purpose of this study is to identify correlates of outcome for SCS. Methods. Data were retrospectively collected on 244 patients who underwent a SCS trial at two academic medical centers. Success was predefined as ≥50% pain relief sustained for ≥6 months. Variables analyzed for their association with outcome included demographics, location of pain, diagnosis, presence of coexisting diseases, pain descriptors, opioid and adjuvant medication use, duration and pain relief during trial, and complications. Results. The presence of allodynia and/or hyperalgesia correlated with both a positive SCS trial (P=0.01) and long-term implantation outcome (P=0.05). History of substance abuse was associated with a negative permanent SCS outcome (P=0.05) but bore no relationship to trial results. The variable most strongly associated with an SCS outcome was experiencing <50% pain relief during the trial, which strongly presaged a negative result (P<0.001). Conclusions. Although weak associations with outcome were noted for several clinical variables, none was strongly associated with trial and permanent implantation results. The strongest predictor of a negative SCS outcome was obtaining <50% pain relief during the trial period. Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)1142-1153
Number of pages12
JournalPain Medicine
Issue number8
StatePublished - Aug 2011


  • Chronic Pain
  • Neuropathy
  • Outcome Assessment
  • Pain Management

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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