TY - GEN
T1 - A model of high-frequency force generation in the constrained cochlear outer hair cell
AU - Liao, Zhijie
AU - Popel, Aleksander S.
AU - Brownell, William E.
AU - Spector, Alexander A.
N1 - Funding Information:
This work was supported by research grants DC02775 and DC00354 from the National Institute of Deafness and Other Communication Disorders (NIH).
Publisher Copyright:
Copyright © 2006 by World Scientific Publishing Co. Pte. Ltd.
PY - 2005
Y1 - 2005
N2 - The cochlear outer hair cell (OHC) has a unique property of electromotility, which is critically important for the sensitivity and frequency selectivity during the mammalian hearing process. The underlying mechanism could be better understood by examining the force generated by the OHC as a feedback to vibration of the basilar membrane. In this study, we propose a model to analyze the effect of the constraints imposed on OHC on the cell’s high-frequency active force generated in vitro and in vivo. The OHC is modeled as a viscoelastic and piezoelectric cylindrical shell coupled with viscous intracellular and extracellular fluids, and the constraint is represented by a spring with adjustable stiffness. We found that constrained OHC can achieve a much higher corner frequency than free OHC, depending on the stiffness of the constraint. We also analyzed cases in which the stiffness of the constraint was similar to that of the basilar membrane, reticular lamina, and tectorial membrane and found that the force per unit transmembrane potential generated by the OHC can be constant up to several tens of kHz.
AB - The cochlear outer hair cell (OHC) has a unique property of electromotility, which is critically important for the sensitivity and frequency selectivity during the mammalian hearing process. The underlying mechanism could be better understood by examining the force generated by the OHC as a feedback to vibration of the basilar membrane. In this study, we propose a model to analyze the effect of the constraints imposed on OHC on the cell’s high-frequency active force generated in vitro and in vivo. The OHC is modeled as a viscoelastic and piezoelectric cylindrical shell coupled with viscous intracellular and extracellular fluids, and the constraint is represented by a spring with adjustable stiffness. We found that constrained OHC can achieve a much higher corner frequency than free OHC, depending on the stiffness of the constraint. We also analyzed cases in which the stiffness of the constraint was similar to that of the basilar membrane, reticular lamina, and tectorial membrane and found that the force per unit transmembrane potential generated by the OHC can be constant up to several tens of kHz.
UR - https://www.scopus.com/pages/publications/85087095781
UR - https://www.scopus.com/pages/publications/85087095781#tab=citedBy
M3 - Conference contribution
AN - SCOPUS:85087095781
T3 - Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium
SP - 202
EP - 209
BT - Auditory Mechanisms
A2 - Nuttall, Alfred L.
A2 - Ren, Tianying
A2 - Gillespie, Peter
A2 - Grosh, Karl
A2 - de Boer, Egbert
PB - World Scientific Publishing Co. Pte Ltd
T2 - 9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005
Y2 - 23 July 2005 through 28 July 2005
ER -