TY - JOUR
T1 - A model international partnership for community-based research on vaccine-preventable diseases
T2 - The Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU)
AU - Gibbons, Robert V.
AU - Nisalak, Ananda
AU - Yoon, In Kyu
AU - Tannitisupawong, Darunee
AU - Rungsimunpaiboon, Kamchai
AU - Vaughn, David W.
AU - Endy, Timothy P.
AU - Innis, Bruce L.
AU - Burke, Donald S.
AU - Mammen, Mammen P.
AU - Scott, Robert Mc Nair
AU - Thomas, Stephen J.
AU - Hoke, Charles H.
PY - 2013/9/23
Y1 - 2013/9/23
N2 - This paper describes an international collaboration to carry out studies that contributed to the understanding of pathogenesis, diagnosis, treatment, and prevention of several diseases of public health importance for Thailand and the United States. In Kamphaeng Phet Province, Thailand, febrile syndromes, including encephalitis, hepatitis, hemorrhagic fever, and influenza-like illnesses, occurred commonly and were clinically diagnosed, but the etiology was rarely confirmed. Since 1982, the Kamphaeng Phet Provincial Hospital, the Thai Ministry of Public Health, and the US Army Component of the Armed Forces Research Institute of Medical Sciences, along with vaccine manufacturers and universities, have collaborated on studies that evaluated and capitalized on improved diagnostic capabilities for infections caused by Japanese encephalitis, hepatitis A, dengue, and influenza viruses. The collaboration clarified clinical and epidemiological features of these infections and, in large clinical trials, demonstrated that vaccines against Japanese encephalitis and hepatitis A viruses were over 90% efficacious, supporting licensure of both vaccines. With the introduction of Japanese encephalitis vaccines in Thailand's Expanded Program on Immunization, reported encephalitis rates dropped substantially. Similarly, in the US, particularly in the military populations, rates of hepatitis A disease have dropped with the use of hepatitis A vaccine. Studies of the pathogenesis of dengue infections have increased understanding of the role of cellular immunity in responding to these infections, and epidemiological studies have prepared the province for studies of dengue vaccines. Approximately 80 publications resulted from this collaboration. Studies conducted in Kamphaeng Phet provided experience that contributed to clinical trials of hepatitis E and HIV vaccines, conducted elsewhere. To provide a base for continuing studies, The Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU) was established. This paper reviews the origins of the collaboration and the scientific observations made between 1982 and 2012.
AB - This paper describes an international collaboration to carry out studies that contributed to the understanding of pathogenesis, diagnosis, treatment, and prevention of several diseases of public health importance for Thailand and the United States. In Kamphaeng Phet Province, Thailand, febrile syndromes, including encephalitis, hepatitis, hemorrhagic fever, and influenza-like illnesses, occurred commonly and were clinically diagnosed, but the etiology was rarely confirmed. Since 1982, the Kamphaeng Phet Provincial Hospital, the Thai Ministry of Public Health, and the US Army Component of the Armed Forces Research Institute of Medical Sciences, along with vaccine manufacturers and universities, have collaborated on studies that evaluated and capitalized on improved diagnostic capabilities for infections caused by Japanese encephalitis, hepatitis A, dengue, and influenza viruses. The collaboration clarified clinical and epidemiological features of these infections and, in large clinical trials, demonstrated that vaccines against Japanese encephalitis and hepatitis A viruses were over 90% efficacious, supporting licensure of both vaccines. With the introduction of Japanese encephalitis vaccines in Thailand's Expanded Program on Immunization, reported encephalitis rates dropped substantially. Similarly, in the US, particularly in the military populations, rates of hepatitis A disease have dropped with the use of hepatitis A vaccine. Studies of the pathogenesis of dengue infections have increased understanding of the role of cellular immunity in responding to these infections, and epidemiological studies have prepared the province for studies of dengue vaccines. Approximately 80 publications resulted from this collaboration. Studies conducted in Kamphaeng Phet provided experience that contributed to clinical trials of hepatitis E and HIV vaccines, conducted elsewhere. To provide a base for continuing studies, The Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU) was established. This paper reviews the origins of the collaboration and the scientific observations made between 1982 and 2012.
KW - Collaboration
KW - Dengue vaccine
KW - Hepatitis A vaccine
KW - Influenza
KW - Japanese encephalitis vaccine
KW - Public Health
KW - Site selection
KW - Team building
KW - Vaccine efficacy trials
UR - http://www.scopus.com/inward/record.url?scp=84883597567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883597567&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2013.07.082
DO - 10.1016/j.vaccine.2013.07.082
M3 - Review article
C2 - 23933334
AN - SCOPUS:84883597567
SN - 0264-410X
VL - 31
SP - 4487
EP - 4500
JO - Vaccine
JF - Vaccine
IS - 41
ER -