A model for tumor cell killing by topoisomerase poisons

H. Zhang, P. D'Arpa, L. F. Liu

Research output: Contribution to journalArticlepeer-review

173 Scopus citations


Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalCancer Cells
Issue number1
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Cancer Research


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