A model for pharmacological research-treatment of cocaine dependence

Ivan D. Montoya, Judith M. Hess, Kenzie L. Preston, David A. Gorelick

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Major problems for research on pharmacological treatments for cocaine dependence are lack of comparability of results from different treatment research programs and poor validity and/or reliability of results. Double-blind, placebo-controlled, random assignment, experimental designs, using standard intake and assessment procedures help to reduce these problems. Cessation or reduction of drug use and/or craving, retention in treatment, and medical and psychosocial improvement are some of the outcome variables collected in treatment research programs. A model to be followed across different outpatient clinical trials for pharmacological treatment of cocaine dependence is presented here. This model represents an effort to standardize data collection to make results more valid and comparable.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalJournal of Substance Abuse Treatment
Issue number6
StatePublished - 1995
Externally publishedYes


  • clinical trials
  • cocaine
  • dependence
  • model
  • pharmacotherapy

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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