@inproceedings{199dc5d0d02a49c0a9a10d55aef12e55,
title = "A model for generating paired complete blood count and oblique back-illumination capillaroscopy data in tissue-realistic microfluidic chambers",
abstract = "Oblique back-illumination capillaroscopy (OBC) has recently demonstrated clear images of unlabeled human blood cells in vivo. Combined with deep learning-based algorithms, this technology may enable non-invasive blood cell counting and analysis as flowing red blood cells, platelets, and white blood cells can be observed in their native environment. To harness the full potential of OBC, new techniques and methods must be developed that provide ground truth data using human blood cells. Here we present such a model, where human blood cells with paired ground truth information are imaged flowing in a custom tissue-mimicking micro fluidic device. This model enables the acquisition of OBC datasets that will help with both training and validating machine learning models for applications including the complete blood count, specific blood cell classification, and the study of hematologic disorders such as anemia.",
keywords = "blood cell imaging, Capillaroscopy, hematology, microfluidics, oblique back-illumination",
author = "McKay, {Gregory N.} and Luojie Huang and Bobrow, {Taylor L.} and Srivathsan Kalyan and Hur, {Soojung Claire} and Sophie Lanzkron and Pecker, {Lydia H.} and Moliterno, {Alison R} and Durr, {Nicholas J.}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX 2022 ; Conference date: 20-02-2022 Through 24-02-2022",
year = "2022",
doi = "10.1117/12.2609715",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Attila Tarnok and Houston, {Jessica P.}",
booktitle = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX",
}