TY - GEN
T1 - A miniature laser speckle contrast imager for monitoring the neuromodulatory effect of transcranial ultrasound stimulation
AU - Zeng, Yinuo
AU - Acord, Molly
AU - Kaovasia, Tarana Parvez
AU - Miao, Peng
AU - Sun, Junfeng
AU - Tong, Shanbao
AU - Curry, Eli
AU - Aghabaglou, Fariba
AU - Theodore, Nicholas
AU - Thakor, Nitish
AU - Manbachi, Amir
N1 - Funding Information:
Nicholas Theodore, Nitish Thakor, and Amir Manbachi acknowledge funding support from Defense Advanced Research Projects Agency, DARPA, Award Contract #: N660012024075. In addition, Amir Manbachi acknowledges funding support from Johns Hopkins Institute for Clinical and Trnsalational Research (ICTR)s’C linical Research Scholars Program (KL2), administered by the National Center for Advancing Translational Sciences (NCATS), National Institute of Health (NIH). Nitish Thakor acknowledges funding support from National Institute of Health (NIH): R01 HL139158-01A1 and R01 HL071568-15.
Funding Information:
Nicholas Theodore, Nitish Thakor, and Amir Manbachi acknowledge funding support from Defense Advanced Research Projects Agency, DARPA, Award Contract #: N660012024075. In addition, Amir Manbachi acknowledges funding support from Johns Hopkins Institute for Clinical and Translational Research (ICTR)'s Clinical Research Scholars Program (KL2), administered by the National Center for Advancing Translational Sciences (NCATS), National Institute of Health (NIH). Nitish Thakor acknowledges funding support from National Institute of Health (NIH): R01 HL139158-01A1 and R01 HL071568-15
Publisher Copyright:
© 2021 by ASME.
PY - 2021
Y1 - 2021
N2 - Transcranial ultrasound stimulation is a neuromodulation technique that is capable of exciting or suppressing the neural network. The neuromodulatory effect on cerebral hemodynamics has been monitored using optical methods like laser speckle contrast imaging in animal studies. However, the bulky size and stationary nature of the imaging system constrains the application of laser speckle contrast imaging on research that requires the animal to be in irregular body positions or to be awake. Here, we present a design using a miniature laser speckle contrast imager to monitor the cerebral blood flow changes during transcranial ultrasound stimulation in a rat model. We demonstrate its feasibility by showing that the results are comparable to those acquired from a traditional benchtop imaging system.
AB - Transcranial ultrasound stimulation is a neuromodulation technique that is capable of exciting or suppressing the neural network. The neuromodulatory effect on cerebral hemodynamics has been monitored using optical methods like laser speckle contrast imaging in animal studies. However, the bulky size and stationary nature of the imaging system constrains the application of laser speckle contrast imaging on research that requires the animal to be in irregular body positions or to be awake. Here, we present a design using a miniature laser speckle contrast imager to monitor the cerebral blood flow changes during transcranial ultrasound stimulation in a rat model. We demonstrate its feasibility by showing that the results are comparable to those acquired from a traditional benchtop imaging system.
KW - Cerebral blood flow
KW - Laser speckle contrast imaging
KW - Neuromodulation
KW - Ultrasound stimulation
UR - http://www.scopus.com/inward/record.url?scp=85107217921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107217921&partnerID=8YFLogxK
U2 - 10.1115/DMD2021-1038
DO - 10.1115/DMD2021-1038
M3 - Conference contribution
AN - SCOPUS:85107217921
T3 - Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021
BT - Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021
PB - American Society of Mechanical Engineers
T2 - 2021 Design of Medical Devices Conference, DMD 2021
Y2 - 12 April 2021 through 15 April 2021
ER -