A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion

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10 Scopus citations


The 4-[18F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [18F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4-[18F]-fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/μmole at end of synthesis.

Original languageEnglish (US)
Pages (from-to)695-698
Number of pages4
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number12
StatePublished - Oct 2014


  • Fluorine-18
  • Microwave
  • Phosphonium
  • Positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry


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