Abstract
Microfluidic devices that can apply stretch stimulation to cells to mimic the in vivo environment of organs have attracted significant attention as an alternative to animal testing in drug discovery screening. However, those devices reported in previous papers were driven by bulky fluid power systems composed of large external pumps and long tubing systems, which occupy much larger space than the main chip-based device itself and limit the number of simultaneous sample processing. Therefore, it is necessary to mount pressure sources on a single chip for miniaturizing the entire system. In this study, we propose to develop and mount MEMS-fabricated micropumps utilizing the strong flow of electro-conjugated fluid (ECF) into the microfluidic devices to stretch a microporous membrane, on which cultured cells can be simulated in various applications. The proposed microfluidic device is successfully fabricated, and its characteristics are investigated experimentally. The experimental results show that the device can stretch the microporous membrane with the strain (5–15%) at a frequency (0.2 Hz) similar to the organs’ in vivo environment, demonstrating the feasibility of making the drug discovery screening efficient and effective.
Original language | English (US) |
---|---|
Article number | 114332 |
Journal | Sensors and Actuators A: Physical |
Volume | 356 |
DOIs | |
State | Published - Jun 16 2023 |
Keywords
- Electro-conjugate fluid (ECF)
- Hydraulic power source
- MEMS
- Micropump
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering