A method for the computational modeling of the physics of heart murmurs

Jung Hee Seo, Hani Bakhshaee, Guillaume Garreau, Chi Zhu, Andreas Andreou, William R. Thompson, Rajat Mittal

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A computational method for direct simulation of the generation and propagation of blood flow induced sounds is proposed. This computational hemoacoustic method is based on the immersed boundary approach and employs high-order finite difference methods to resolve wave propagation and scattering accurately. The current method employs a two-step, one-way coupled approach for the sound generation and its propagation through the tissue. The blood flow is simulated by solving the incompressible Navier-Stokes equations using the sharp-interface immersed boundary method, and the equations corresponding to the generation and propagation of the three-dimensional elastic wave corresponding to the murmur are resolved with a high-order, immersed boundary based, finite-difference methods in the time-domain. The proposed method is applied to a model problem of aortic stenosis murmur and the simulation results are verified and validated by comparing with known solutions as well as experimental measurements. The murmur propagation in a realistic model of a human thorax is also simulated by using the computational method. The roles of hemodynamics and elastic wave propagation on the murmur are discussed based on the simulation results.

Original languageEnglish (US)
Pages (from-to)546-568
Number of pages23
JournalJournal of Computational Physics
StatePublished - May 1 2017


  • Cardiovascular flow
  • Elastic waves
  • Heart sound
  • Hemodynamics
  • Immersed boundary method
  • Systolic murmur

ASJC Scopus subject areas

  • Numerical Analysis
  • Modeling and Simulation
  • Physics and Astronomy (miscellaneous)
  • General Physics and Astronomy
  • Computer Science Applications
  • Computational Mathematics
  • Applied Mathematics


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