A method for event-related phase/amplitude coupling

Bradley Voytek, Mark D'Esposito, Nathan Crone, Robert T. Knight

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Phase/amplitude coupling (PAC) is emerging as an important electrophysiological measure of local and long-distance neuronal communication. Current techniques for calculating PAC provide a numerical index that represents an average value across an arbitrarily long time period. This requires researchers to rely on block design experiments and temporal concatenation at the cost of the sub-second temporal resolution afforded by electrophysiological recordings. Here we present a method for calculating event-related phase/amplitude coupling (ERPAC) designed to capture the temporal evolution of task-related changes in PAC across events or between distant brain regions that is applicable to human or animal electromagnetic recording.

Original languageEnglish (US)
Pages (from-to)416-424
Number of pages9
Issue number1
StatePublished - Jan 1 2013


  • Alpha
  • Cross-frequency coupling
  • Electrocorticography
  • Electrophysiology
  • Gamma
  • Phase/amplitude coupling
  • Theta

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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