A mechanistic theory to explain the efficacy of antiretroviral therapy

Sarah B. Laskey, Robert F. Siliciano

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


In the early years of the AIDS epidemic, a diagnosis of HIV.1 infection was equivalent to a death sentence. The development of combination antiretroviral therapy (cART) in the 1990s to combat HIV.1 infection was one of the most impressive achievements of medical science. Today, patients who are treated early with cART can expect a near-normal lifespan. In this Opinion article, we propose a fundamental theory to explain the mechanistic basis of cART and why it works so well, including a model to assess and predict the efficacy of antiretroviral drugs alone or in combination.

Original languageEnglish (US)
Pages (from-to)772-780
Number of pages9
JournalNature Reviews Microbiology
Issue number11
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Microbiology
  • General Immunology and Microbiology
  • Infectious Diseases


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