A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

Keyphrases

• Reactive Oxygen Species 100%
• Hematopoietic Stem Cells 100%
• Oxygenic 100%
• Self-renewal 10%
• Antioxidant 10%
• Signaling Pathway 10%
• Rapamycin 10%
• Quiescence 10%
• Bone Marrow 10%
• Mammalian Target of Rapamycin (mTOR) 10%
• Notch1 10%
• Stem Cell Activation 10%
• Stem Cell Population 10%
• Cell-Associated 10%
• P38 Mitogen-activated Protein Kinase (p38 MAPK) 10%
• Calcium-sensing Receptor (CaSR) 10%
• N-cadherin 10%
• Long-term Protection 10%
• Reactive Oxygen Stress 10%
• MAPK Inhibitors 10%
• Intracellular Reactive Oxygen Species 10%
• Serial Transplantation 10%
• Physical Access 10%
• Stem Cell Exhaustion 10%
• Osteoblastic Niche 10%
• Reactive Oxygen Species Generation 10%
• Higher Self 10%
• Species Activity 10%

Immunology and Microbiology

• Hematopoietic Cell 100%
• Dioxygen 100%
• Sirolimus 20%
• Mitogen 10%
• Signal Transduction 10%
• Cell Population 10%
• Cell Function 10%
• Neural Cell Adhesion Molecule 10%
• Kinase 10%
• Phosphotransferase 10%

Biochemistry, Genetics and Molecular Biology

• Hematopoietic Cell 100%
• Cell Function 11%
• Signal Transduction 11%
• P21 11%
• Mechanistic Target of Rapamycin 11%
• Neural Cell Adhesion Molecule 11%
• Hematopoietic Stem Cell Niche 11%
• P38 Mitogen-Activated Protein Kinases 11%