A longitudinal study on a-synuclein in blood plasma as a biomarker for Parkinson's disease

Penelope G. Foulds; Peter Diggle; J. Douglas Mitchell; Angela Parker; Masato Hasegawa; Masami Masuda-Suzukake; David M A Mann; David Allsop

doi:10.1038/srep02540

A longitudinal study on a-synuclein in blood plasma as a biomarker for Parkinson's disease

Penelope G. Foulds, Peter Diggle, J. Douglas Mitchell, Angela Parker, Masato Hasegawa, Masami Masuda-Suzukake, David M A Mann, David Allsop

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Abstract

There have been no longitudinal studies on a-synuclein as a potential biomarker for the progression of Parkinson's disease (PD). Here, blood plasma 'total a-synuclein' and 'Ser-129 phosphorylated α-synuclein' were assayed at 4-6 monthly intervals from a cohort of 189 newly-diagnosed patients with PD. For log-transformed data, plasma total a-synuclein levels increased with time for up to 20 yrs after the appearance of initial symptoms (p 5 0.012), whereas phosphorylated α-synuclein remained constant over this same period. The mean level of phosphorylated a-synuclein, but not of total a-synuclein, was higher in the PD plasma samples taken at first visit than in single samples taken from a group of 91 healthy controls (p50.012). Overall, we conclude that the plasma level of phosphorylated α-synuclein has potential value as a diagnostic tool, whereas the level of total a-synuclein could act as a surrogate marker for the progression of PD.

Original language	English (US)
Article number	2540
Journal	Scientific Reports
Volume	3
DOIs	https://doi.org/10.1038/srep02540
State	Published - Aug 29 2013
Externally published	Yes

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title = "A longitudinal study on a-synuclein in blood plasma as a biomarker for Parkinson's disease",

abstract = "There have been no longitudinal studies on a-synuclein as a potential biomarker for the progression of Parkinson's disease (PD). Here, blood plasma 'total a-synuclein' and 'Ser-129 phosphorylated α-synuclein' were assayed at 4-6 monthly intervals from a cohort of 189 newly-diagnosed patients with PD. For log-transformed data, plasma total a-synuclein levels increased with time for up to 20 yrs after the appearance of initial symptoms (p 5 0.012), whereas phosphorylated α-synuclein remained constant over this same period. The mean level of phosphorylated a-synuclein, but not of total a-synuclein, was higher in the PD plasma samples taken at first visit than in single samples taken from a group of 91 healthy controls (p50.012). Overall, we conclude that the plasma level of phosphorylated α-synuclein has potential value as a diagnostic tool, whereas the level of total a-synuclein could act as a surrogate marker for the progression of PD.",

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AU - Foulds, Penelope G.

AU - Diggle, Peter

AU - Mitchell, J. Douglas

AU - Parker, Angela

AU - Hasegawa, Masato

AU - Masuda-Suzukake, Masami

AU - Mann, David M A

AU - Allsop, David

PY - 2013/8/29

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N2 - There have been no longitudinal studies on a-synuclein as a potential biomarker for the progression of Parkinson's disease (PD). Here, blood plasma 'total a-synuclein' and 'Ser-129 phosphorylated α-synuclein' were assayed at 4-6 monthly intervals from a cohort of 189 newly-diagnosed patients with PD. For log-transformed data, plasma total a-synuclein levels increased with time for up to 20 yrs after the appearance of initial symptoms (p 5 0.012), whereas phosphorylated α-synuclein remained constant over this same period. The mean level of phosphorylated a-synuclein, but not of total a-synuclein, was higher in the PD plasma samples taken at first visit than in single samples taken from a group of 91 healthy controls (p50.012). Overall, we conclude that the plasma level of phosphorylated α-synuclein has potential value as a diagnostic tool, whereas the level of total a-synuclein could act as a surrogate marker for the progression of PD.

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A longitudinal study on a-synuclein in blood plasma as a biomarker for Parkinson's disease

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