A longitudinal study of Giardia lamblia infection in north-east Brazilian children

Robert D. Newman, Sean R. Moore, Aldo A.M. Lima, James P. Nataro, Richard L. Guerrant, Cynthia L. Sears

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


OBJECTIVE: To evaluate the epidemiology of Giardia lamblia infection, investigate factors which might be associated with clinical manifestations and recurrence, and examine the role of copathogens in disease course. METHODS: Prospective 4-year cohort study of children born in an urban slum in north-eastern Brazil. RESULTS: Of 157 children followed for ≥ 3 months, 43 (27.4%) were infected with Giardia. The organism was identified in 8.8% of all stool specimens, and although found with similar frequency in non-diarrhoeal (7.4%) and diarrhoeal stools (9.7%), was more common in children with persistent (20.6%) than acute diarrhoea (7.6%, P = 0.002). Recurrent or relapsing infections were common (46%). Children with symptomatic infections had significantly lower weight-for-age and height-for-age than asymptomatic children. Copathogens were not associated with disease course. CONCLUSION: With its protean clinical manifestations, Giardia may be associated with substantial morbidity amongst children in Brazil.

Original languageEnglish (US)
Pages (from-to)624-634
Number of pages11
JournalTropical Medicine and International Health
Issue number8
StatePublished - 2001


  • Asymptomatic
  • Brazil
  • Child
  • Diarrhoea
  • Giardia lamblia
  • Malnutrition

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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