@article{20eaebdb5c7841318e85b9f21194f4ae,
title = "A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers",
abstract = "West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18–50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50–65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.",
keywords = "West Nile virus, flavivirus, vaccine",
author = "Pierce, {Kristen K.} and Whitehead, {Stephen S.} and Kirkpatrick, {Beth D.} and Grier, {Palmtama L.} and Adrienne Jarvis and Heather Kenney and Carmolli, {Marya P.} and Cynthia Reynolds and Tibery, {Cecilia M.} and Janece Lovchik and Anna Janiak and Luke, {Catherine J.} and Durbin, {Anna P.} and Pletnev, {Alexander G.}",
note = "Funding Information: Financial support. This work was supported by the National Institute of Allergy and Infectious Disease Intramural Research Program, National Institutes of Health (contract HHSN272200900010C). Publisher Copyright: {\textcopyright} The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. F.",
year = "2017",
month = jan,
day = "1",
doi = "10.1093/INFDIS/JIW501",
language = "English (US)",
volume = "215",
pages = "52--55",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",
}