A homeobox gene essential for zebrafish notochord development

William S. Talbot; Bill Trevarrow; Marnie E. Halpern; Anna E. Melby; Gist Farr; John H. Postlethwait; Trevor Jowett; Charles B. kimmel; David Kimelman

doi:10.1038/378150a0

A homeobox gene essential for zebrafish notochord development

William S. Talbot, Bill Trevarrow, Marnie E. Halpern, Anna E. Melby, Gist Farr, John H. Postlethwait, Trevor Jowett, Charles B. kimmel, David Kimelman

Research output: Contribution to journal › Article › peer-review

398 Scopus citations

Abstract

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

Original language	English (US)
Pages (from-to)	145-149
Number of pages	5
Journal	Nature
Volume	378
Issue number	6553
DOIs	https://doi.org/10.1038/378150a0
State	Published - Nov 9 1995
Externally published	Yes

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title = "A homeobox gene essential for zebrafish notochord development",

abstract = "The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.",

author = "Talbot, {William S.} and Bill Trevarrow and Halpern, {Marnie E.} and Melby, {Anna E.} and Gist Farr and Postlethwait, {John H.} and Trevor Jowett and kimmel, {Charles B.} and David Kimelman",

note = "Funding Information: ACKNOWIEI~EMI~'.ZrS We thank C. MingheUi for expel| technical help. This work was made possible by grants from die Association Fmn~;aise con|re les Myopathies (AFM).",

year = "1995",

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doi = "10.1038/378150a0",

language = "English (US)",

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T1 - A homeobox gene essential for zebrafish notochord development

AU - Talbot, William S.

AU - Trevarrow, Bill

AU - Halpern, Marnie E.

AU - Melby, Anna E.

AU - Farr, Gist

AU - Postlethwait, John H.

AU - Jowett, Trevor

AU - kimmel, Charles B.

AU - Kimelman, David

N1 - Funding Information: ACKNOWIEI~EMI~'.ZrS We thank C. MingheUi for expel| technical help. This work was made possible by grants from die Association Fmn~;aise con|re les Myopathies (AFM).

PY - 1995/11/9

Y1 - 1995/11/9

N2 - The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

AB - The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

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A homeobox gene essential for zebrafish notochord development

Abstract

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