@article{f55c6d9b4a674ded9467b970e8c49e0f,
title = "A glioneuronal tumor with CLIP2-MET fusion",
abstract = "We report a case of glioneuronal tumor (GNT) with a discovery of novel gene fusion of CLIP2-MET resulting from aberrant chromosome 7 abnormalities. We executed an elaborate genomic study on this case including whole-exome sequencing and RNA sequencing. Genomic analysis of the tumor revealed aberrations in chromosomes 1 and 7 and a CLIP2-MET fusion. Further analysis of the upregulated genes revealed substantial connections with MAPK pathway activation. We concluded that the chromosome 7 abnormalities prompted CLIP2-MET gene fusion which successively leads to MAPK pathway activation. We deliberated that MAPK pathway activation is one of the driver pathways responsible for the oncogenesis of GNT.",
author = "Tamrin Chowdhury and Yeajina Lee and Sojin Kim and Yu, {Hyeon Jong} and Ji, {So Young} and Bae, {Jeong Mo} and Won, {Jae Kyung} and Shin, {Joo Heon} and Weinberger, {Daniel R.} and Choi, {Seung Hong} and Park, {Chul Kee} and Kim, {Jong Il} and Park, {Sung Hye}",
note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program (NRF-2018M3A9H3021707) and the Basic Science Research Program (NRF-2019R1A2C2005144) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT of Republic of Korea. We appreciate all the help from German Cancer Research Center (DKFZ), especially to Stefan Pfister and Martin Sill. We thank Hye Jung Hong, R.N. for her support on laboratory management of this study. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41525-020-0131-6",
language = "English (US)",
volume = "5",
journal = "npj Genomic Medicine",
issn = "2056-7944",
publisher = "Nature Publishing Group",
number = "1",
}