A glioneuronal tumor with CLIP2-MET fusion

Tamrin Chowdhury, Yeajina Lee, Sojin Kim, Hyeon Jong Yu, So Young Ji, Jeong Mo Bae, Jae Kyung Won, Joo Heon Shin, Daniel R. Weinberger, Seung Hong Choi, Chul Kee Park, Jong Il Kim, Sung Hye Park

Research output: Contribution to journalArticlepeer-review


We report a case of glioneuronal tumor (GNT) with a discovery of novel gene fusion of CLIP2-MET resulting from aberrant chromosome 7 abnormalities. We executed an elaborate genomic study on this case including whole-exome sequencing and RNA sequencing. Genomic analysis of the tumor revealed aberrations in chromosomes 1 and 7 and a CLIP2-MET fusion. Further analysis of the upregulated genes revealed substantial connections with MAPK pathway activation. We concluded that the chromosome 7 abnormalities prompted CLIP2-MET gene fusion which successively leads to MAPK pathway activation. We deliberated that MAPK pathway activation is one of the driver pathways responsible for the oncogenesis of GNT.

Original languageEnglish (US)
Article number24
Journalnpj Genomic Medicine
Issue number1
StatePublished - Dec 1 2020

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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