A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy

A. E. Ross; F. Y. Feng; M. Ghadessi; N. Erho; A. Crisan; C. Buerki; D. Sundi; A. P. Mitra; I. A. Vergara; D. J S Thompson; T. J. Triche; E. Davicioni; E. J. Bergstralh; R. B. Jenkins; R. J. Karnes; E. M. Schaeffer

doi:10.1038/pcan.2013.49

A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy

A. E. Ross, F. Y. Feng, M. Ghadessi, N. Erho, A. Crisan, C. Buerki, D. Sundi, A. P. Mitra, I. A. Vergara, D. J S Thompson, T. J. Triche, E. Davicioni, E. J. Bergstralh, R. B. Jenkins, R. J. Karnes, E. M. Schaeffer

School of Medicine

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Background:Due to their varied outcomes, men with biochemical recurrence (BCR) following radical prostatectomy (RP) present a management dilemma. Here, we evaluate Decipher, a genomic classifier (GC), for its ability to predict metastasis following BCR.Methods:The study population included 85 clinically high-risk patients who developed BCR after RP. Time-dependent receiver operating characteristic (ROC) curves, weighted Cox proportional hazard models and decision curves were used to compare GC scores to Gleason score (GS), PSA doubling time (PSAdT), time to BCR (ttBCR), the Stephenson nomogram and CAPRA-S for predicting metastatic disease progression. All tests were two-sided with a type I error probability of 5%.Results:GC scores stratified men with BCR into those who would or would not develop metastasis (8% of patients with low versus 40% with high scores developed metastasis, P

Original language	English (US)
Pages (from-to)	64-69
Number of pages	6
Journal	Prostate Cancer and Prostatic Diseases
Volume	17
Issue number	1
DOIs	https://doi.org/10.1038/pcan.2013.49
State	Published - Mar 2014

Keywords

biochemical recurrence
clinical validation
genomic classifier
metastasis
prognostic models

ASJC Scopus subject areas

Oncology
Urology
Cancer Research
Medicine(all)

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10.1038/pcan.2013.49

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Ross, A. E., Feng, F. Y., Ghadessi, M., Erho, N., Crisan, A., Buerki, C., Sundi, D., Mitra, A. P., Vergara, I. A., Thompson, D. J. S., Triche, T. J., Davicioni, E., Bergstralh, E. J., Jenkins, R. B., Karnes, R. J., & Schaeffer, E. M. (2014). A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy. Prostate Cancer and Prostatic Diseases, 17(1), 64-69. https://doi.org/10.1038/pcan.2013.49

Ross, AE, Feng, FY, Ghadessi, M, Erho, N, Crisan, A, Buerki, C, Sundi, D, Mitra, AP, Vergara, IA, Thompson, DJS, Triche, TJ, Davicioni, E, Bergstralh, EJ, Jenkins, RB, Karnes, RJ & Schaeffer, EM 2014, 'A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy', Prostate Cancer and Prostatic Diseases, vol. 17, no. 1, pp. 64-69. https://doi.org/10.1038/pcan.2013.49

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abstract = "Background:Due to their varied outcomes, men with biochemical recurrence (BCR) following radical prostatectomy (RP) present a management dilemma. Here, we evaluate Decipher, a genomic classifier (GC), for its ability to predict metastasis following BCR.Methods:The study population included 85 clinically high-risk patients who developed BCR after RP. Time-dependent receiver operating characteristic (ROC) curves, weighted Cox proportional hazard models and decision curves were used to compare GC scores to Gleason score (GS), PSA doubling time (PSAdT), time to BCR (ttBCR), the Stephenson nomogram and CAPRA-S for predicting metastatic disease progression. All tests were two-sided with a type I error probability of 5%.Results:GC scores stratified men with BCR into those who would or would not develop metastasis (8% of patients with low versus 40% with high scores developed metastasis, P",

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author = "Ross, {A. E.} and Feng, {F. Y.} and M. Ghadessi and N. Erho and A. Crisan and C. Buerki and D. Sundi and Mitra, {A. P.} and Vergara, {I. A.} and Thompson, {D. J S} and Triche, {T. J.} and E. Davicioni and Bergstralh, {E. J.} and Jenkins, {R. B.} and Karnes, {R. J.} and Schaeffer, {E. M.}",

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doi = "10.1038/pcan.2013.49",

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AU - Ross, A. E.

AU - Feng, F. Y.

AU - Ghadessi, M.

AU - Erho, N.

AU - Crisan, A.

AU - Buerki, C.

AU - Sundi, D.

AU - Mitra, A. P.

AU - Vergara, I. A.

AU - Thompson, D. J S

AU - Triche, T. J.

AU - Davicioni, E.

AU - Bergstralh, E. J.

AU - Jenkins, R. B.

AU - Karnes, R. J.

AU - Schaeffer, E. M.

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A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy

Abstract

Keywords

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