A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans

Bonnie A. Thiel; Aravinda Chakravarti; Richard S. Cooper; Amy Luke; Sue Lewis; Audrey Lynn; Hemant Tiwari; Nicholas J. Schork; Alan B. Weder

doi:10.1016/S0895-7061(02)03246-6

A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans

Bonnie A. Thiel, Aravinda Chakravarti, Richard S. Cooper, Amy Luke, Sue Lewis, Audrey Lynn, Hemant Tiwari, Nicholas J. Schork, Alan B. Weder

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the GenNet network of the National Heart, Lung and Blood Institute-sponsored Family Blood Pressure Program. Multipoint regression and variance components linkage methods were used to analyze 372 polymorphic markers. Statistically compelling evidence for linkage (P values .0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large.

Original language	English (US)
Pages (from-to)	151-153
Number of pages	3
Journal	American Journal of Hypertension
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/S0895-7061(02)03246-6
State	Published - Feb 1 2003
Externally published	Yes

Keywords

Blood pressure
Genetics
Heredity
Hypertension
Linkage analysis

ASJC Scopus subject areas

Internal Medicine

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10.1016/S0895-7061(02)03246-6

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title = "A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans",

abstract = "Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the GenNet network of the National Heart, Lung and Blood Institute-sponsored Family Blood Pressure Program. Multipoint regression and variance components linkage methods were used to analyze 372 polymorphic markers. Statistically compelling evidence for linkage (P values .0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large.",

keywords = "Blood pressure, Genetics, Heredity, Hypertension, Linkage analysis",

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note = "Funding Information: This work was supported by National Heart, Lung and Blood Institute (NHLBI) grants HL 45508 and HL 47910 as part of the NHLBI{\textquoteright}s Family Blood Pressure Program. ",

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AU - Thiel, Bonnie A.

AU - Chakravarti, Aravinda

AU - Cooper, Richard S.

AU - Luke, Amy

AU - Lewis, Sue

AU - Lynn, Audrey

AU - Tiwari, Hemant

AU - Schork, Nicholas J.

AU - Weder, Alan B.

N1 - Funding Information: This work was supported by National Heart, Lung and Blood Institute (NHLBI) grants HL 45508 and HL 47910 as part of the NHLBI’s Family Blood Pressure Program.

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N2 - Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the GenNet network of the National Heart, Lung and Blood Institute-sponsored Family Blood Pressure Program. Multipoint regression and variance components linkage methods were used to analyze 372 polymorphic markers. Statistically compelling evidence for linkage (P values .0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large.

AB - Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the GenNet network of the National Heart, Lung and Blood Institute-sponsored Family Blood Pressure Program. Multipoint regression and variance components linkage methods were used to analyze 372 polymorphic markers. Statistically compelling evidence for linkage (P values .0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large.

KW - Blood pressure

KW - Genetics

KW - Heredity

KW - Hypertension

KW - Linkage analysis

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A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans

Abstract

Keywords

ASJC Scopus subject areas

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