A genome-wide association study of DSM-IV: Cannabis dependence

Arpana Agrawal; Michael T. Lynskey; Anthony Hinrichs; Richard Grucza; Scott F. Saccone; Robert Krueger; Rosalind Neuman; William Howells; Sherri Fisher; Louis Fox; Robert Cloninger; Danielle M. Dick; Kimberly F. Doheny; Howard J. Edenberg; Alison M. Goate; Victor Hesselbrock; Eric Johnson; John Kramer; Samuel Kuperman; John I. Nurnberger; Elizabeth Pugh; Marc Schuckit; Jay Tischfield; John P. Rice; Kathleen K. Bucholz; Laura J. Bierut

doi:10.1111/j.1369-1600.2010.00255.x

A genome-wide association study of DSM-IV: Cannabis dependence

Arpana Agrawal
, Michael T. Lynskey
, Anthony Hinrichs
, Richard Grucza
, Scott F. Saccone
, Robert Krueger
, Rosalind Neuman
, William Howells
, Sherri Fisher
, Louis Fox
, Robert Cloninger
, Danielle M. Dick
, Kimberly F. Doheny
, Howard J. Edenberg
, Alison M. Goate
, Victor Hesselbrock
, Eric Johnson
, John Kramer
, Samuel Kuperman
, John I. Nurnberger

Elizabeth Pugh, Marc Schuckit, Jay Tischfield, John P. Rice, Kathleen K. Bucholz, Laura J. Bierut

School of Medicine

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.

Original language	English (US)
Pages (from-to)	514-518
Number of pages	5
Journal	Addiction Biology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1111/j.1369-1600.2010.00255.x
State	Published - Jul 2011

Keywords

Association
Cannabis dependence
Case-control
DSM
Genomewide
PLINK

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology
Psychiatry and Mental health

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10.1111/j.1369-1600.2010.00255.x

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Agrawal, A., Lynskey, M. T., Hinrichs, A., Grucza, R., Saccone, S. F., Krueger, R., Neuman, R., Howells, W., Fisher, S., Fox, L., Cloninger, R., Dick, D. M., Doheny, K. F., Edenberg, H. J., Goate, A. M., Hesselbrock, V., Johnson, E., Kramer, J., Kuperman, S., ... Bierut, L. J. (2011). A genome-wide association study of DSM-IV: Cannabis dependence. Addiction Biology, 16(3), 514-518. https://doi.org/10.1111/j.1369-1600.2010.00255.x

Agrawal, A, Lynskey, MT, Hinrichs, A, Grucza, R, Saccone, SF, Krueger, R, Neuman, R, Howells, W, Fisher, S, Fox, L, Cloninger, R, Dick, DM, Doheny, KF, Edenberg, HJ, Goate, AM, Hesselbrock, V, Johnson, E, Kramer, J, Kuperman, S, Nurnberger, JI, Pugh, E, Schuckit, M, Tischfield, J, Rice, JP, Bucholz, KK & Bierut, LJ 2011, 'A genome-wide association study of DSM-IV: Cannabis dependence', Addiction Biology, vol. 16, no. 3, pp. 514-518. https://doi.org/10.1111/j.1369-1600.2010.00255.x

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abstract = "Despite twin studies showing that 50-70\% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.",

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A genome-wide association study of DSM-IV: Cannabis dependence

Abstract

Keywords

ASJC Scopus subject areas

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