A genome screen of 76 families ascertained through two autism probands

Susan Folstein; Jonathan Haines; Rebecca Landa; Joe Piven; Susan Santangelo; Val Sheffield; Veronica Vieland

A genome screen of 76 families ascertained through two autism probands

Susan Folstein, Jonathan Haines, Rebecca Landa, Joe Piven, Susan Santangelo, Val Sheffield, Veronica Vieland

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The CLSA is a formal collaboration among three clinical data collection sites and two laboratories, funded through the NIMH (USA) to carry out a genetic linkage study of autism. The goal is to genotype 150 families in two replicate samples. We are currently completing our first genome screen of 76 families, including 72 sibling pairs and 4 sibling trios and 148 of 153 possible parents. There are several instances of non-Mendelian transmission of markers on chromosome 15q. At the time of the conference, we will present the statistical analysis of the entire genome screen, as well as results from our follow-up of chromosomal regions (e.g., 7, 15, 16) previously reported as providing suggestive evidence of linkage to autism.

Original language	English (US)
Number of pages	1
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	81
Issue number	6
State	Published - Nov 6 1998

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

Cite this

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AU - Folstein, Susan

AU - Haines, Jonathan

AU - Landa, Rebecca

AU - Piven, Joe

AU - Santangelo, Susan

AU - Sheffield, Val

AU - Vieland, Veronica

PY - 1998/11/6

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AB - The CLSA is a formal collaboration among three clinical data collection sites and two laboratories, funded through the NIMH (USA) to carry out a genetic linkage study of autism. The goal is to genotype 150 families in two replicate samples. We are currently completing our first genome screen of 76 families, including 72 sibling pairs and 4 sibling trios and 148 of 153 possible parents. There are several instances of non-Mendelian transmission of markers on chromosome 15q. At the time of the conference, we will present the statistical analysis of the entire genome screen, as well as results from our follow-up of chromosomal regions (e.g., 7, 15, 16) previously reported as providing suggestive evidence of linkage to autism.

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A genome screen of 76 families ascertained through two autism probands

Abstract

ASJC Scopus subject areas

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