A genetic polymorphism in the CYP19A1 gene and the risk of hypertension among midlife women

Ayelet Ziv-Gal, Lisa Gallicchio, Susan R Miller, Howard A. Zacur, Jodi A. Flaws

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: To test whether a synonymous single nucleotide polymorphism (A → G; rs700518) in the CYP19A1 gene, which encodes the enzyme aromatase, is associated with an increased risk for hypertension of midlife women. Methods: In a cross-sectional study, 639 midlife women were recruited. Eligible women had their blood pressure, weight and height measured, and donated a blood sample for hormone and genetic analyses. The participants also completed a detailed study survey. Women were grouped according to their genotype, blood pressure measurements, and medical history. The data were analyzed using logistic and linear regression models. The study had 80% power to detect small differences in mean systolic blood pressure (SBP; 4.5 mmHg) and diastolic blood pressure (DBP; 3 mmHg). Results: The selected polymorphism was significantly associated with hypertension and SBP in unadjusted analyses. Interestingly, women with hypertension were more likely to be homozygous for the A allele (AA) compared to women who were not categorized as having hypertension. Further, the mean SBP was significantly higher for women who were homozygous for the A allele when compared to women carrying the other genotypes (AG or GG). The unadjusted association between DBP values and genotype was of borderline statistical significance (p = 0.07). However, after adjustment for potential confounders (age, race, body mass index (BMI), smoking and physical activity), the associations between genotype and hypertension/blood pressure were attenuated and not statistically significant. Conclusion: The rs700518 polymorphism in the CYP19A1 is not associated with hypertension in our sample of midlife women. Other factors, including race and BMI, appear to play a greater role.

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
Issue number1
StatePublished - Jan 2012


  • CYP19A1
  • Estrogen
  • Hypertension
  • Polymorphism
  • Race
  • Women

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Obstetrics and Gynecology


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