A framework of whole heart extracellular volume fraction estimation for low dose cardiac CT images

Xinjian Chen, Ronald M. Summers, Marcelo Souto Nacif, Songtao Liu, David A. Bluemke, Jianhua Yao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


Cardiac magnetic resonance imaging (CMRI) has been well validated and allows quantification of myocardial fibrosis in comparison to overall mass of the myocardium. Unfortunately, CMRI is relatively expensive and is contraindicated in patients with intracardiac devices. Cardiac CT (CCT) is widely available and has been validated for detection of scar and myocardial stress/rest perfusion. In this paper, we sought to evaluate the potential of low dose CCT for the measurement of myocardial whole heart extracellular volume (ECV) fraction. A novel framework was proposed for CCT whole heart ECV estimation, which consists of three main steps. First, a shape constrained graph cut (GC) method was proposed for myocardium and blood pool segmentation for post-contrast image. Second, the symmetric Demons deformable registrations method was applied to register pre-contrast to post-contrast images. Finally, the whole heart ECV value was computed. The proposed method was tested on 7 clinical low dose CCT datasets with pre-contrast and post-contrast images. The preliminary results demonstrated the feasibility and efficiency of the proposed method.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2012
Subtitle of host publicationImage Processing
StatePublished - 2012
Externally publishedYes
EventMedical Imaging 2012: Image Processing - San Diego, CA, United States
Duration: Feb 6 2012Feb 9 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2012: Image Processing
Country/TerritoryUnited States
CitySan Diego, CA


  • Demons
  • Graph cut
  • Live wire
  • Myocardium segmentation
  • Registration

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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