A framework for concepts of reserve and resilience in aging

Yaakov Stern; Marilyn Albert; Carol A. Barnes; Roberto Cabeza; Alvaro Pascual-Leone; Peter R. Rapp

doi:10.1016/j.neurobiolaging.2022.10.015

A framework for concepts of reserve and resilience in aging

Yaakov Stern, Marilyn Albert, Carol A. Barnes, Roberto Cabeza, Alvaro Pascual-Leone, Peter R. Rapp

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The study of factors, across species, that allow some individuals to age more successfully than others has important implications for individual wellbeing as well as health education, policy and intervention. Design of studies and communication across investigators in this area has been hampered by a diversity of terminology. The Collaboratory on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia was funded by the National Institute on Aging and established in 2019 as a 3-year process of developing consensus definitions and research guidelines. The proposed Framework is based on an iterative process including 3 annual Workshops, focused workgroups, and input from numerous international investigators. It suggests the overarching term: resilience, and presents operational definitions for 3 concepts: cognitive reserve, brain maintenance, and brain reserve. Twelve pilot studies that integrate these definitions are presented. The use of a common vocabulary and operational definitions will facilitate even greater progress in understanding the factors that are associated with successful aging.

Original language	English (US)
Pages (from-to)	100-103
Number of pages	4
Journal	Neurobiology of aging
Volume	124
DOIs	https://doi.org/10.1016/j.neurobiolaging.2022.10.015
State	Published - Apr 2023

Keywords

Brain maintenance
Brain reserve
Cognitive reserve
Resilience

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Aging
General Neuroscience
Developmental Biology

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10.1016/j.neurobiolaging.2022.10.015

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title = "A framework for concepts of reserve and resilience in aging",

abstract = "The study of factors, across species, that allow some individuals to age more successfully than others has important implications for individual wellbeing as well as health education, policy and intervention. Design of studies and communication across investigators in this area has been hampered by a diversity of terminology. The Collaboratory on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia was funded by the National Institute on Aging and established in 2019 as a 3-year process of developing consensus definitions and research guidelines. The proposed Framework is based on an iterative process including 3 annual Workshops, focused workgroups, and input from numerous international investigators. It suggests the overarching term: resilience, and presents operational definitions for 3 concepts: cognitive reserve, brain maintenance, and brain reserve. Twelve pilot studies that integrate these definitions are presented. The use of a common vocabulary and operational definitions will facilitate even greater progress in understanding the factors that are associated with successful aging.",

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AU - Stern, Yaakov

AU - Albert, Marilyn

AU - Barnes, Carol A.

AU - Cabeza, Roberto

AU - Pascual-Leone, Alvaro

AU - Rapp, Peter R.

PY - 2023/4

Y1 - 2023/4

N2 - The study of factors, across species, that allow some individuals to age more successfully than others has important implications for individual wellbeing as well as health education, policy and intervention. Design of studies and communication across investigators in this area has been hampered by a diversity of terminology. The Collaboratory on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia was funded by the National Institute on Aging and established in 2019 as a 3-year process of developing consensus definitions and research guidelines. The proposed Framework is based on an iterative process including 3 annual Workshops, focused workgroups, and input from numerous international investigators. It suggests the overarching term: resilience, and presents operational definitions for 3 concepts: cognitive reserve, brain maintenance, and brain reserve. Twelve pilot studies that integrate these definitions are presented. The use of a common vocabulary and operational definitions will facilitate even greater progress in understanding the factors that are associated with successful aging.

AB - The study of factors, across species, that allow some individuals to age more successfully than others has important implications for individual wellbeing as well as health education, policy and intervention. Design of studies and communication across investigators in this area has been hampered by a diversity of terminology. The Collaboratory on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia was funded by the National Institute on Aging and established in 2019 as a 3-year process of developing consensus definitions and research guidelines. The proposed Framework is based on an iterative process including 3 annual Workshops, focused workgroups, and input from numerous international investigators. It suggests the overarching term: resilience, and presents operational definitions for 3 concepts: cognitive reserve, brain maintenance, and brain reserve. Twelve pilot studies that integrate these definitions are presented. The use of a common vocabulary and operational definitions will facilitate even greater progress in understanding the factors that are associated with successful aging.

KW - Brain maintenance

KW - Brain reserve

KW - Cognitive reserve

KW - Resilience

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VL - 124

SP - 100

EP - 103

JO - Neurobiology of aging

JF - Neurobiology of aging

ER -

A framework for concepts of reserve and resilience in aging

Abstract

Keywords

ASJC Scopus subject areas

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