A Family History Study of Neuropsychiatric Disorders in the Adult Siblings of Autistic Individuals

JOSEPH PIVEN; JEANNE GAYLE; GARY A. CHASE; BARBIE FINK; REBECCA LANDA; MARYANN M. WZOREK; SUSAN E. FOLSTEIN

doi:10.1097/00004583-199003000-00004

A Family History Study of Neuropsychiatric Disorders in the Adult Siblings of Autistic Individuals

JOSEPH PIVEN, JEANNE GAYLE, GARY A. CHASE, BARBIE FINK, REBECCA LANDA, MARYANN M. WZOREK, SUSAN E. FOLSTEIN

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

153 Scopus citations

Abstract

The family history method was used to obtain developmental, social, and psychiatric histories on the 67 adult siblings of 37 autistic probands. Two of 67 siblings (3.0%) were autistic, three siblings (4.4%) had severe social dysfunction and isolation, 10 (15%) had cognitive disorders, and 10 (15%) had received treatment for affective disorder. This study is the first to investigate the frequency of disorders in the adult siblings of autistic probands. These results suggest aggregation of a variety of neuropsychiatric disorders in the siblings of autistic individuals.

Original language	English (US)
Pages (from-to)	177-183
Number of pages	7
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	29
Issue number	2
DOIs	https://doi.org/10.1097/00004583-199003000-00004
State	Published - 1990

Keywords

affective disorder
autism
cognitive disorder
genetics

ASJC Scopus subject areas

Developmental and Educational Psychology
Psychiatry and Mental health

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10.1097/00004583-199003000-00004

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title = "A Family History Study of Neuropsychiatric Disorders in the Adult Siblings of Autistic Individuals",

abstract = "The family history method was used to obtain developmental, social, and psychiatric histories on the 67 adult siblings of 37 autistic probands. Two of 67 siblings (3.0%) were autistic, three siblings (4.4%) had severe social dysfunction and isolation, 10 (15%) had cognitive disorders, and 10 (15%) had received treatment for affective disorder. This study is the first to investigate the frequency of disorders in the adult siblings of autistic probands. These results suggest aggregation of a variety of neuropsychiatric disorders in the siblings of autistic individuals.",

keywords = "affective disorder, autism, cognitive disorder, genetics",

author = "JOSEPH PIVEN and JEANNE GAYLE and CHASE, {GARY A.} and BARBIE FINK and REBECCA LANDA and WZOREK, {MARYANN M.} and FOLSTEIN, {SUSAN E.}",

note = "Funding Information: Accepted September 21, 1989. From the Department of Psychiatry, Divisions of Psychiatric Genetics and Child Psychiatry. The Johns Hopkins University, School of Medicine. This study was supported in part by NIMH Grant ROI MH39936-01. The John Merck Fund (Dr. Piveni. and the Stallone Fund for Autism Research. Reprint requests to DrPiven, The Johns Hopkins Hospital, Meyer 2-/8/,600 North Wolfe Street, Baltimore, Maryland 2/205. 0890-8567/9012902-0 177$02.0010{\textcopyright} 1990 by the American Academy of Child and Adolescent Psychiatry.",

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AU - PIVEN, JOSEPH

AU - GAYLE, JEANNE

AU - CHASE, GARY A.

AU - FINK, BARBIE

AU - LANDA, REBECCA

AU - WZOREK, MARYANN M.

AU - FOLSTEIN, SUSAN E.

N1 - Funding Information: Accepted September 21, 1989. From the Department of Psychiatry, Divisions of Psychiatric Genetics and Child Psychiatry. The Johns Hopkins University, School of Medicine. This study was supported in part by NIMH Grant ROI MH39936-01. The John Merck Fund (Dr. Piveni. and the Stallone Fund for Autism Research. Reprint requests to DrPiven, The Johns Hopkins Hospital, Meyer 2-/8/,600 North Wolfe Street, Baltimore, Maryland 2/205. 0890-8567/9012902-0 177$02.0010© 1990 by the American Academy of Child and Adolescent Psychiatry.

PY - 1990

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N2 - The family history method was used to obtain developmental, social, and psychiatric histories on the 67 adult siblings of 37 autistic probands. Two of 67 siblings (3.0%) were autistic, three siblings (4.4%) had severe social dysfunction and isolation, 10 (15%) had cognitive disorders, and 10 (15%) had received treatment for affective disorder. This study is the first to investigate the frequency of disorders in the adult siblings of autistic probands. These results suggest aggregation of a variety of neuropsychiatric disorders in the siblings of autistic individuals.

AB - The family history method was used to obtain developmental, social, and psychiatric histories on the 67 adult siblings of 37 autistic probands. Two of 67 siblings (3.0%) were autistic, three siblings (4.4%) had severe social dysfunction and isolation, 10 (15%) had cognitive disorders, and 10 (15%) had received treatment for affective disorder. This study is the first to investigate the frequency of disorders in the adult siblings of autistic probands. These results suggest aggregation of a variety of neuropsychiatric disorders in the siblings of autistic individuals.

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KW - autism

KW - cognitive disorder

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A Family History Study of Neuropsychiatric Disorders in the Adult Siblings of Autistic Individuals

Abstract

Keywords

ASJC Scopus subject areas

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