A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones

Ki Wha Lee, Young Hoon Choi, Yung Hyup Joo, Jin Kwan Kim, Song Seok Shin, Young Joo Byun, Yeonjoon Kim, Shin Chung

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the 'hard soft acid base' principle. The reaction scope of 2-bromoisobutyryl cyanide could be expanded to prepare a variety of 2,2-dimethyl-3(2H)-furanone derivatives other than 4,5-diaryl-2,2-dimethyl-3(2H)-furanones.

Original languageEnglish (US)
Pages (from-to)1137-1142
Number of pages6
JournalBioorganic and Medicinal Chemistry
Issue number4
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science


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