A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones

Ki Wha Lee; Young Hoon Choi; Yung Hyup Joo; Jin Kwan Kim; Song Seok Shin; Young Joo Byun; Yeonjoon Kim; Shin Chung

doi:10.1016/S0968-0896(01)00388-1

A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones

Ki Wha Lee, Young Hoon Choi, Yung Hyup Joo, Jin Kwan Kim, Song Seok Shin, Young Joo Byun, Yeonjoon Kim, Shin Chung

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the 'hard soft acid base' principle. The reaction scope of 2-bromoisobutyryl cyanide could be expanded to prepare a variety of 2,2-dimethyl-3(2H)-furanone derivatives other than 4,5-diaryl-2,2-dimethyl-3(2H)-furanones.

Original language	English (US)
Pages (from-to)	1137-1142
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/S0968-0896(01)00388-1
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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title = "A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones",

abstract = "An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the 'hard soft acid base' principle. The reaction scope of 2-bromoisobutyryl cyanide could be expanded to prepare a variety of 2,2-dimethyl-3(2H)-furanone derivatives other than 4,5-diaryl-2,2-dimethyl-3(2H)-furanones.",

author = "Lee, {Ki Wha} and Choi, {Young Hoon} and Joo, {Yung Hyup} and Kim, {Jin Kwan} and Shin, {Song Seok} and Byun, {Young Joo} and Yeonjoon Kim and Shin Chung",

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doi = "10.1016/S0968-0896(01)00388-1",

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T1 - A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones

AU - Lee, Ki Wha

AU - Choi, Young Hoon

AU - Joo, Yung Hyup

AU - Kim, Jin Kwan

AU - Shin, Song Seok

AU - Byun, Young Joo

AU - Kim, Yeonjoon

AU - Chung, Shin

PY - 2002

Y1 - 2002

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AB - An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the 'hard soft acid base' principle. The reaction scope of 2-bromoisobutyryl cyanide could be expanded to prepare a variety of 2,2-dimethyl-3(2H)-furanone derivatives other than 4,5-diaryl-2,2-dimethyl-3(2H)-furanones.

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A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones

Abstract

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