Methods for a facile high-yielding synthesis of substituted pyrazolo[3,4-c]pyridines from 2-bromo-5-fluoropyridine are described, along with a brief mechanistic discussion for the key cyclization step. The methods utilize inexpensive commercially available starting materials and unlike previous methods, are more suitable for SAR work and scale-up.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jan 28 2009|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry