A facile method for the synthesis of substituted pyrazolo[3,4-c]pyridines

Sharad K. Verma; Louis V. LaFrance

doi:10.1016/j.tetlet.2008.11.013

A facile method for the synthesis of substituted pyrazolo[3,4-c]pyridines

Sharad K. Verma, Louis V. LaFrance

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Methods for a facile high-yielding synthesis of substituted pyrazolo[3,4-c]pyridines from 2-bromo-5-fluoropyridine are described, along with a brief mechanistic discussion for the key cyclization step. The methods utilize inexpensive commercially available starting materials and unlike previous methods, are more suitable for SAR work and scale-up.

Original language	English (US)
Pages (from-to)	383-385
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	4
DOIs	https://doi.org/10.1016/j.tetlet.2008.11.013
State	Published - Jan 28 2009
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2008.11.013

Cite this

@article{39e503d71aaf498faac753014d716e11,

title = "A facile method for the synthesis of substituted pyrazolo[3,4-c]pyridines",

abstract = "Methods for a facile high-yielding synthesis of substituted pyrazolo[3,4-c]pyridines from 2-bromo-5-fluoropyridine are described, along with a brief mechanistic discussion for the key cyclization step. The methods utilize inexpensive commercially available starting materials and unlike previous methods, are more suitable for SAR work and scale-up.",

author = "Verma, {Sharad K.} and LaFrance, {Louis V.}",

year = "2009",

month = jan,

day = "28",

doi = "10.1016/j.tetlet.2008.11.013",

language = "English (US)",

volume = "50",

pages = "383--385",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - A facile method for the synthesis of substituted pyrazolo[3,4-c]pyridines

AU - Verma, Sharad K.

AU - LaFrance, Louis V.

PY - 2009/1/28

Y1 - 2009/1/28

N2 - Methods for a facile high-yielding synthesis of substituted pyrazolo[3,4-c]pyridines from 2-bromo-5-fluoropyridine are described, along with a brief mechanistic discussion for the key cyclization step. The methods utilize inexpensive commercially available starting materials and unlike previous methods, are more suitable for SAR work and scale-up.

AB - Methods for a facile high-yielding synthesis of substituted pyrazolo[3,4-c]pyridines from 2-bromo-5-fluoropyridine are described, along with a brief mechanistic discussion for the key cyclization step. The methods utilize inexpensive commercially available starting materials and unlike previous methods, are more suitable for SAR work and scale-up.

UR - http://www.scopus.com/inward/record.url?scp=57149132513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57149132513&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2008.11.013

DO - 10.1016/j.tetlet.2008.11.013

M3 - Article

AN - SCOPUS:57149132513

SN - 0040-4039

VL - 50

SP - 383

EP - 385

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

A facile method for the synthesis of substituted pyrazolo[3,4-c]pyridines

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this