A dose-finding study of liposomal daunorubicin with CVP (COP-X) in advanced NHL

I. W. Flinn, S. N. Goodman, L. Post, J. Jamison, C. B. Miller, S. Gore, L. Diehl, C. Willis, R. F. Ambinder, J. C. Byrd

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: Standard therapy for lymphoma consists of a cyclophosphamide (C), doxorubicin, vincristine (V), and prednisone (P) (CHOP) combination regimen. Liposomal daunorubicin (DaunoXome®) is an alternative to doxorubicin for patients with lymphoma because of its more favorable safety profile and potentially more selective uptake in lymphoma. The objectives of this study were to determine the maximum tolerated dose (MTD) of liposomal daunorubucin with CVP (COP-X) and the tolerability of the regimen in patients with indolent lymphoma. Patients and methods: Patients with low-grade and intermediate-grade lymphoma having adequate cardiac, hepatic, and renal function were enrolled. Patients received C 750 mg/m2, V 1.4 mg/m2 (maximum 2.0 mg), and liposomal daunorubicin 50-100 mg/m2 i.v. on day 1 and P 100 mg p.o. on days 1-5. MTD was the liposomal daunorubicin dose associated with 20% dose-limiting toxicity (ANC < 500/mm3 for > 5 days or febrile neutropenia). Results: Twenty patients, median age 59 years, were treated. The liposomal daunorubicin MTD combined with CVP was 70-80 mg/m2, depending on patient population. No significant non-hematologic toxicity occurred. Response rate was 44% (2 complete and 5 partial responses). Conclusions: A liposomal daunorubicin dose of 80 mg/m2 in the COP-X regimen was well tolerated with little non-hematologic toxicity.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalAnnals of Oncology
Issue number6
StatePublished - 2000


  • Anthracycline
  • Chemotherapy
  • Liposomal daunorubicin
  • Lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology


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