A dinosaurian facial deformity and the first occurrence of ameloblastoma in the fossil record

Mihai D. DumbrǍ; Bruce M. Rothschild; David B. Weishampel; Zoltán Csiki-Sava; RǍzvan A. Andrei; Katharine A. Acheson; Vlad A. Codrea

doi:10.1038/srep29271

A dinosaurian facial deformity and the first occurrence of ameloblastoma in the fossil record

Mihai D. DumbrǍ, Bruce M. Rothschild, David B. Weishampel, Zoltán Csiki-Sava, RǍzvan A. Andrei, Katharine A. Acheson, Vlad A. Codrea

School of Medicine

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Abstract

Despite documentation of various types of neoplastic pathologies encountered in the vertebrate fossil record, no ameloblastic tumours have been recognised so far. Ameloblastoma is a benign neoplasic tumour with a strong preponderance for the mandible. Here, we report for the first time the presence of an ameloblastoma neoplasm in the lower jaw of a specimen referred to the derived non-hadrosaurid hadrosauroid dinosaur Telmatosaurus transsylvanicus from the uppermost Cretaceous of the Haeg Basin in Romania. The location, external appearance and internal structure of the pathological outgrowth provide clear evidence for the diagnosis of ameloblastoma in Telmatosaurus. This report extends the range of pathologies encountered in hadrosauroid dinosaurs. In addition, recognition of an ameloblastoma neoplasm in a taxon lying close to the origin of 'duck-billed' hadrosaurid dinosaurs confirms the predisposition of this clade towards neoplasia pathologies already in its basal members.

Original language	English (US)
Article number	29271
Journal	Scientific reports
Volume	6
DOIs	https://doi.org/10.1038/srep29271
State	Published - Jul 5 2016

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title = "A dinosaurian facial deformity and the first occurrence of ameloblastoma in the fossil record",

abstract = "Despite documentation of various types of neoplastic pathologies encountered in the vertebrate fossil record, no ameloblastic tumours have been recognised so far. Ameloblastoma is a benign neoplasic tumour with a strong preponderance for the mandible. Here, we report for the first time the presence of an ameloblastoma neoplasm in the lower jaw of a specimen referred to the derived non-hadrosaurid hadrosauroid dinosaur Telmatosaurus transsylvanicus from the uppermost Cretaceous of the Haeg Basin in Romania. The location, external appearance and internal structure of the pathological outgrowth provide clear evidence for the diagnosis of ameloblastoma in Telmatosaurus. This report extends the range of pathologies encountered in hadrosauroid dinosaurs. In addition, recognition of an ameloblastoma neoplasm in a taxon lying close to the origin of 'duck-billed' hadrosaurid dinosaurs confirms the predisposition of this clade towards neoplasia pathologies already in its basal members.",

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note = "Funding Information: The authors thank Mr. Enrico Zamparo of SCANCO Medical AG for the invitation to use their micro-CT scanning facilities, and Dr. Lisa Falco (SCANCO Medical AG) for performing the micro-CT scans. Funding was provided in part by CNCS grant PN-II-ID-PCE-2011-3-0381 (to V.A.C., Z.Cs.-S.), and grant POSDRU/159/1.5/S/132400 (to M.D.D.).",

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A dinosaurian facial deformity and the first occurrence of ameloblastoma in the fossil record

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