A CTD function linking transcription to splicing

Jeffry L. Corden, Meera Patturajan

Research output: Contribution to journalComment/debatepeer-review

145 Scopus citations


Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

Original languageEnglish (US)
Pages (from-to)413-416
Number of pages4
JournalTrends in biochemical sciences
Issue number11
StatePublished - Nov 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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