A CTD function linking transcription to splicing

Jeffry L. Corden; Meera Patturajan

doi:10.1016/S0968-0004(97)01125-0

A CTD function linking transcription to splicing

Jeffry L. Corden, Meera Patturajan

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

145 Scopus citations

Abstract

Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

Original language	English (US)
Pages (from-to)	413-416
Number of pages	4
Journal	Trends in biochemical sciences
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/S0968-0004(97)01125-0
State	Published - Nov 1997

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/S0968-0004(97)01125-0

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title = "A CTD function linking transcription to splicing",

abstract = "Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.",

author = "Corden, {Jeffry L.} and Meera Patturajan",

note = "Funding Information: Acknowledgements We wish to thank S. Warren, D. Bentley and D. Price for sharing results before publication and for helpful comments on the manuscript. Work in the authors' laboratory was supported by grants from the NIH (GM53600) and",

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AU - Corden, Jeffry L.

AU - Patturajan, Meera

N1 - Funding Information: Acknowledgements We wish to thank S. Warren, D. Bentley and D. Price for sharing results before publication and for helpful comments on the manuscript. Work in the authors' laboratory was supported by grants from the NIH (GM53600) and

PY - 1997/11

Y1 - 1997/11

N2 - Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

AB - Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

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JO - Trends in biochemical sciences

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A CTD function linking transcription to splicing

Abstract

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