TY - JOUR
T1 - A cross-sectional study of the association between chronic hepatitis c virus infection and subclinical coronary atherosclerosis among participants in the multicenter AIDS cohort study
AU - Mckibben, Rebeccah A.
AU - Haberlen, Sabina A.
AU - Post, Wendy S.
AU - Brown, Todd T.
AU - Budoff, Matthew
AU - Witt, Mallory D.
AU - Kingsley, Lawrence A.
AU - Palella, Frank J.
AU - Thio, Chloe L.
AU - Seaberg, Eric C.
N1 - Publisher Copyright:
© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2016/1/15
Y1 - 2016/1/15
N2 - Background. Hepatitis C virus (HCV) infection may increase the risk of cardiovascular disease (CVD). We evaluated the association of chronic HCV infection and coronary atherosclerosis among participants in the Multicenter AIDS Cohort Study. Methods. We assessed 994 men with or without human immunodeficiency virus (HIV) infection (87 of whom had chronic HCV infection) for coronary plaque, using noncontrast coronary computed tomography (CT); 755 also underwent CT angiography. We then evaluated the associations of chronic HCV infection and HIV infection with measures of plaque prevalence, extent, and stenosis. Results. After adjustment for demographic characteristics, HIV serostatus, behaviors, and CVD risk factors, chronic HCV infection was significantly associated with a higher prevalence of coronary artery calcium (prevalence ratio, 1.29; 95% confidence interval [CI], 1.02-1.63), any plaque (prevalence ratio, 1.26; 95% CI, 1.09-1.45), and noncalcified plaque (prevalence ratio, 1.42; 95% CI, 1.16-1.75). Chronic HCV infection and HIV infection were independently associated with the prevalence of any plaque and of noncalcified plaque, but there was no evidence of a synergistic effect due to HIV/HCV coinfection. The prevalences of coronary artery calcium, any plaque, noncalcified plaque, a mixture of noncalcified and calcified plaque, and calcified plaque were significantly higher among men with an HCV RNA load of ≥2 × 106 IU/mL, compared with findings among men without chronic HCV infection. Conclusions. Chronic HCV infection is associated with subclinical CVD, suggesting that vigilant assessments of cardiovascular risk are warranted for HCV-infected individuals. Future research should determine whether HCV infection duration or HCV treatment influence coronary plaque development.
AB - Background. Hepatitis C virus (HCV) infection may increase the risk of cardiovascular disease (CVD). We evaluated the association of chronic HCV infection and coronary atherosclerosis among participants in the Multicenter AIDS Cohort Study. Methods. We assessed 994 men with or without human immunodeficiency virus (HIV) infection (87 of whom had chronic HCV infection) for coronary plaque, using noncontrast coronary computed tomography (CT); 755 also underwent CT angiography. We then evaluated the associations of chronic HCV infection and HIV infection with measures of plaque prevalence, extent, and stenosis. Results. After adjustment for demographic characteristics, HIV serostatus, behaviors, and CVD risk factors, chronic HCV infection was significantly associated with a higher prevalence of coronary artery calcium (prevalence ratio, 1.29; 95% confidence interval [CI], 1.02-1.63), any plaque (prevalence ratio, 1.26; 95% CI, 1.09-1.45), and noncalcified plaque (prevalence ratio, 1.42; 95% CI, 1.16-1.75). Chronic HCV infection and HIV infection were independently associated with the prevalence of any plaque and of noncalcified plaque, but there was no evidence of a synergistic effect due to HIV/HCV coinfection. The prevalences of coronary artery calcium, any plaque, noncalcified plaque, a mixture of noncalcified and calcified plaque, and calcified plaque were significantly higher among men with an HCV RNA load of ≥2 × 106 IU/mL, compared with findings among men without chronic HCV infection. Conclusions. Chronic HCV infection is associated with subclinical CVD, suggesting that vigilant assessments of cardiovascular risk are warranted for HCV-infected individuals. Future research should determine whether HCV infection duration or HCV treatment influence coronary plaque development.
KW - atherosclerosis
KW - cardiovascular disease
KW - hepatitis C virus infection
KW - human immunodeficiency virus type 1
KW - plaque
UR - http://www.scopus.com/inward/record.url?scp=84959875088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959875088&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiv396
DO - 10.1093/infdis/jiv396
M3 - Article
C2 - 26216904
AN - SCOPUS:84959875088
SN - 0022-1899
VL - 213
SP - 257
EP - 265
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -