TY - JOUR
T1 - A critical role for interleukin-1β in the progression of autoimmune diseases
AU - Zhao, Ruijuan
AU - Zhou, Hongyan
AU - Su, Shao Bo
N1 - Funding Information:
This project was supported in part by the grants from Guangdong Natural Science Foundation ( S2011010006048 ) and the Fundamental Research Funds of State Key Laboratory of Ophthalmology ( 303060202400439 ).
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - Interleukin-1β (IL-1β) belongs to IL-1 family and is a potent pro-inflammatory cytokine. It is known to be also involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. In addition to its pathophysiologic role in host protection, IL-1β promotes the progression of a number of autoimmune diseases. Most of such diseases can be controlled by anti-IL-1β treatment. This review discusses the contribution of IL-1β to the course of autoimmune diseases, such as rheumatic diseases, uveitis, autoimmune thyroid diseases (AITD), insulin-dependent diabetes mellitus (IDDM), autoimmune inner ear disease (AIED), multiple sclerosis (MS), myocarditis, hepatitis and kidney diseases. The critical involvement of IL-1β in the pathogenesis of autoimmune diseases provides targets for developing therapeutic treatment.
AB - Interleukin-1β (IL-1β) belongs to IL-1 family and is a potent pro-inflammatory cytokine. It is known to be also involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. In addition to its pathophysiologic role in host protection, IL-1β promotes the progression of a number of autoimmune diseases. Most of such diseases can be controlled by anti-IL-1β treatment. This review discusses the contribution of IL-1β to the course of autoimmune diseases, such as rheumatic diseases, uveitis, autoimmune thyroid diseases (AITD), insulin-dependent diabetes mellitus (IDDM), autoimmune inner ear disease (AIED), multiple sclerosis (MS), myocarditis, hepatitis and kidney diseases. The critical involvement of IL-1β in the pathogenesis of autoimmune diseases provides targets for developing therapeutic treatment.
KW - Autoimmune diseases
KW - Biological therapy
KW - Interleukin-1β
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U2 - 10.1016/j.intimp.2013.08.012
DO - 10.1016/j.intimp.2013.08.012
M3 - Review article
C2 - 24012439
AN - SCOPUS:84883676742
SN - 1567-5769
VL - 17
SP - 658
EP - 669
JO - International immunopharmacology
JF - International immunopharmacology
IS - 3
ER -