TY - JOUR
T1 - A coupled chemo-fluidic computational model for thrombogenesis in infarcted left ventricles
AU - Seo, Jung Hee
AU - Abd, Thura
AU - George, Richard
AU - Mittal, Rajat
N1 - Funding Information:
This research is supported by the National Science Foundation (NSF) through Grants IOS-1124804, IIS-1344772, and CBET-1511200. This work used the Extreme Science and Engineering Discovery Environment, which is supported by NSF Grant TG-CTS100002. This work was also made possible by support from the Johns Hopkins Medicine Discovery Fund.
Publisher Copyright:
© 2016 the American Physiological Society.
PY - 2016/6
Y1 - 2016/6
N2 - A coupled chemo-fluidic computational model for investigating flow-mediated thrombogenesis in infarcted left ventricles (LVs) is pro-posed. LV thrombus (LVT) formation after the acute myocardial infarction (AMI) may lead to thromboembolic events that are associ-ated with high mortality and morbidity, and reliable stratification of LVT risk is the key to managing the treatment of AMI patients. There have been several studies emphasizing the importance of LV blood flow patterns on thrombus formation; however, given the complex interplay between ventricular flow dynamics and biochemistry of throm-bogenesis, current understanding is mostly empirical. In the present model, blood flow in the LV is obtained by solving the incompressible Navier-Stokes equations, and this is coupled to the biochemical modeling of the coagulation cascade, platelet activation, and fibrinogen polym-erization. The coupled model is used to examine the effect of ven-tricular flow patterns on thrombogenesis in modeled ventricles. It is expected that the method developed here will enable in-depth studies of thrombogenesis in patient-derived infarcted LV models.
AB - A coupled chemo-fluidic computational model for investigating flow-mediated thrombogenesis in infarcted left ventricles (LVs) is pro-posed. LV thrombus (LVT) formation after the acute myocardial infarction (AMI) may lead to thromboembolic events that are associ-ated with high mortality and morbidity, and reliable stratification of LVT risk is the key to managing the treatment of AMI patients. There have been several studies emphasizing the importance of LV blood flow patterns on thrombus formation; however, given the complex interplay between ventricular flow dynamics and biochemistry of throm-bogenesis, current understanding is mostly empirical. In the present model, blood flow in the LV is obtained by solving the incompressible Navier-Stokes equations, and this is coupled to the biochemical modeling of the coagulation cascade, platelet activation, and fibrinogen polym-erization. The coupled model is used to examine the effect of ven-tricular flow patterns on thrombogenesis in modeled ventricles. It is expected that the method developed here will enable in-depth studies of thrombogenesis in patient-derived infarcted LV models.
KW - Biochemical reaction
KW - Blood clot
KW - Cardiac flow
KW - Coagulation cascade
KW - Computational hemodynamics
KW - Intraventricular flow
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U2 - 10.1152/ajpheart.00855.2015
DO - 10.1152/ajpheart.00855.2015
M3 - Article
C2 - 27016582
AN - SCOPUS:84983786889
SN - 0363-6135
VL - 310
SP - H1567-H1582
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 11
ER -