TY - JOUR
T1 - A core outcome set for acute necrotizing pancreatitis
T2 - An Eastern Association for the Surgery of Trauma modified Delphi method consensus study
AU - Farrell, Michael S.
AU - Alseidi, Adanan
AU - Byerly, Saskya
AU - Fockens, Paul
AU - Giberson, Frederick A.
AU - Glaser, Jeffrey
AU - Horvath, Karen
AU - Jones, David
AU - Luckhurst, Casey
AU - Mowery, Nathan
AU - Robinson, Bryce R.H.
AU - Rodriguez, Allie
AU - Singh, Vikesh K.
AU - Siriwardena, Ajith K.
AU - Vege, Santhi Swaroop
AU - Trikudanathan, Guru
AU - Visser, Brendan C.
AU - Voermans, Rogier P.
AU - Yeh, Daniel Dante
AU - Gelbard, Rondi B.
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - BACKGROUND The management of acute necrotizing pancreatitis (ANP) has changed dramatically over the past 20 years including the use of less invasive techniques, the timing of interventions, nutritional management, and antimicrobial management. This study sought to create a core outcome set (COS) to help shape future research by establishing a minimal set of essential outcomes that will facilitate future comparisons and pooling of data while minimizing reporting bias. METHODS A modified Delphi process was performed through involvement of ANP content experts. Each expert proposed a list of outcomes for consideration, and the panel anonymously scored the outcomes on a 9-point Likert scale. Core outcome consensus defined a priori as >70% of scores receiving 7 to 9 points and <15% of scores receiving 1 to 3 points. Feedback and aggregate data were shared between rounds with interclass correlation trends used to determine the end of the study. RESULTS A total of 19 experts agreed to participate in the study with 16 (84%) participating through study completion. Forty-three outcomes were initially considered with 16 reaching consensuses after four rounds of the modified Delphi process. The final COS included outcomes related to mortality, organ failure, complications, interventions/management, and social factors. CONCLUSION Through an iterative consensus process, content experts agreed on a COS for the management of ANP. This will help shape future research to generate data suitable for pooling and other statistical analyses that may guide clinical practice. LEVEL OF EVIDENCE Therapeutic/Care Management; Level V.
AB - BACKGROUND The management of acute necrotizing pancreatitis (ANP) has changed dramatically over the past 20 years including the use of less invasive techniques, the timing of interventions, nutritional management, and antimicrobial management. This study sought to create a core outcome set (COS) to help shape future research by establishing a minimal set of essential outcomes that will facilitate future comparisons and pooling of data while minimizing reporting bias. METHODS A modified Delphi process was performed through involvement of ANP content experts. Each expert proposed a list of outcomes for consideration, and the panel anonymously scored the outcomes on a 9-point Likert scale. Core outcome consensus defined a priori as >70% of scores receiving 7 to 9 points and <15% of scores receiving 1 to 3 points. Feedback and aggregate data were shared between rounds with interclass correlation trends used to determine the end of the study. RESULTS A total of 19 experts agreed to participate in the study with 16 (84%) participating through study completion. Forty-three outcomes were initially considered with 16 reaching consensuses after four rounds of the modified Delphi process. The final COS included outcomes related to mortality, organ failure, complications, interventions/management, and social factors. CONCLUSION Through an iterative consensus process, content experts agreed on a COS for the management of ANP. This will help shape future research to generate data suitable for pooling and other statistical analyses that may guide clinical practice. LEVEL OF EVIDENCE Therapeutic/Care Management; Level V.
KW - Acute necrotizing pancreatitis
KW - core outcomes
KW - pancreatitis
UR - http://www.scopus.com/inward/record.url?scp=85194176266&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85194176266&partnerID=8YFLogxK
U2 - 10.1097/TA.0000000000004281
DO - 10.1097/TA.0000000000004281
M3 - Article
C2 - 38407209
AN - SCOPUS:85194176266
SN - 2163-0755
VL - 96
SP - 965
EP - 970
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
IS - 6
ER -