Abstract
Interactions between the Tax transactivator of human T-cell leukemia virus type 1 (HTLV-1) and a cell cycle regulatory protein have been examined. We report cooperative stimulation of human immunodeficiency virus type 1 gene expression by Tax and a regulator of cell cycle progression, the p21 cyclin-dependent kinase inhibitor (CKI). This cooperativity results from the effect of p21 on transcriptional coactivation by Tax-induced NF-κB. This effect was abrogated by a mutation in Tax which specifically eliminated NF-κB induction, was inhibitable by IκB-α, and was markedly reduced in human immunodeficiency virus reporter plasmids with mutant κB sites. These studies demonstrate that transcriptional activation by Tax is influenced by cell cycle regulatory proteins.
Original language | English (US) |
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Pages (from-to) | 5731-5734 |
Number of pages | 4 |
Journal | Journal of Virology |
Volume | 70 |
Issue number | 8 |
State | Published - Aug 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology