A convenient preparation of protected 2’-0-methylguansine

Thomas E. Leonard; Purshotam Bhan; Paul S. Miller

doi:10.1080/07328319208018335

A convenient preparation of protected 2’-0-methylguansine

Thomas E. Leonard, Purshotam Bhan, Paul S. Miller

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Protected guanosine nucleosides can be converted directly to their 2’-0-methyl derivatives by methylation with trimethyl silyldiazomethane in the presence of stannous chloride. This procedure circumvents the need to use the potentially hazardous reagent, diazomethane.

Original language	English (US)
Pages (from-to)	1201-1204
Number of pages	4
Journal	Nucleosides and Nucleotides
Volume	11
Issue number	6
DOIs	https://doi.org/10.1080/07328319208018335
State	Published - Jul 1 1992
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Genetics

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10.1080/07328319208018335

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title = "A convenient preparation of protected 2{\textquoteright}-0-methylguansine",

abstract = "Protected guanosine nucleosides can be converted directly to their 2{\textquoteright}-0-methyl derivatives by methylation with trimethyl silyldiazomethane in the presence of stannous chloride. This procedure circumvents the need to use the potentially hazardous reagent, diazomethane.",

author = "Leonard, {Thomas E.} and Purshotam Bhan and Miller, {Paul S.}",

note = "Funding Information: Acknowledgement The research described in this report was supported in part by grants from the National Cancer Institute (CA 42762) and from the Department o f Energy (DEFGO 288ER 60636).",

year = "1992",

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doi = "10.1080/07328319208018335",

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AU - Bhan, Purshotam

AU - Miller, Paul S.

N1 - Funding Information: Acknowledgement The research described in this report was supported in part by grants from the National Cancer Institute (CA 42762) and from the Department o f Energy (DEFGO 288ER 60636).

PY - 1992/7/1

Y1 - 1992/7/1

N2 - Protected guanosine nucleosides can be converted directly to their 2’-0-methyl derivatives by methylation with trimethyl silyldiazomethane in the presence of stannous chloride. This procedure circumvents the need to use the potentially hazardous reagent, diazomethane.

AB - Protected guanosine nucleosides can be converted directly to their 2’-0-methyl derivatives by methylation with trimethyl silyldiazomethane in the presence of stannous chloride. This procedure circumvents the need to use the potentially hazardous reagent, diazomethane.

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A convenient preparation of protected 2’-0-methylguansine

Abstract

ASJC Scopus subject areas

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