A convenient preparation of protected 2’-0-methylguansine

Thomas E. Leonard, Purshotam Bhan, Paul S. Miller

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Protected guanosine nucleosides can be converted directly to their 2’-0-methyl derivatives by methylation with trimethyl silyldiazomethane in the presence of stannous chloride. This procedure circumvents the need to use the potentially hazardous reagent, diazomethane.

Original languageEnglish (US)
Pages (from-to)1201-1204
Number of pages4
JournalNucleosides and Nucleotides
Issue number6
StatePublished - Jul 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics


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