A consensus on the diagnosis and treatment of acromegaly comorbidities: An update

Andrea Giustina; Ariel Barkan; Albert Beckers; Nienke Biermasz; Beverly M.K. Biller; Cesar Boguszewski; Marek Bolanowski; Vivien Bonert; Marcello D. Bronstein; Felipe F. Casanueva; David Clemmons; Annamaria Colao; Diego Ferone; Maria Fleseriu; Stefano Frara; Monica R. Gadelha; Ezio Ghigo; Mark Gurnell; Anthony P. Heaney; Ken Ho; Adriana Ioachimescu; Laurence Katznelson; Fahrettin Kelestimur; John Kopchick; Michal Krsek; Steven Lamberts; Marco Losa; Anton Luger; Pietro Maffei; Monica Marazuela; Gherardo Mazziotti; Moises Mercado; Pietro Mortini; Sebastian Neggers; Alberto M. Pereira; Stephan Petersenn; Manel Puig-Domingo; Roberto Salvatori; Ilan Shimon; Christian Strasburger; Stylianos Tsagarakis; A. J. van der Lely; John Wass; Maria Chiara Zatelli; Shlomo Melmed

doi:10.1210/clinem/dgz096

A consensus on the diagnosis and treatment of acromegaly comorbidities: An update

Andrea Giustina, Ariel Barkan, Albert Beckers, Nienke Biermasz, Beverly M.K. Biller, Cesar Boguszewski, Marek Bolanowski, Vivien Bonert, Marcello D. Bronstein, Felipe F. Casanueva, David Clemmons, Annamaria Colao, Diego Ferone, Maria Fleseriu, Stefano Frara, Monica R. Gadelha, Ezio Ghigo, Mark Gurnell, Anthony P. Heaney, Ken HoAdriana Ioachimescu, Laurence Katznelson, Fahrettin Kelestimur, John Kopchick, Michal Krsek, Steven Lamberts, Marco Losa, Anton Luger, Pietro Maffei, Monica Marazuela, Gherardo Mazziotti, Moises Mercado, Pietro Mortini, Sebastian Neggers, Alberto M. Pereira, Stephan Petersenn, Manel Puig-Domingo, Roberto Salvatori, Ilan Shimon, Christian Strasburger, Stylianos Tsagarakis, A. J. van der Lely, John Wass, Maria Chiara Zatelli, Shlomo Melmed

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013. Participants: The Consensus Group, convened by 11 Steering Committee members, consisted of 45 experts in the medical and surgical management of acromegaly. The authors received no corporate funding or remuneration. Evidence: This evidence-based consensus was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence following critical discussion of the current literature on the diagnosis and treatment of acromegaly comorbidities. Consensus Process: Acromegaly Consensus Group participants conducted comprehensive literature searches for English-language papers on selected topics, reviewed brief presentations on each topic, and discussed current practice and recommendations in breakout groups. Consensus recommendations were developed based on all presentations and discussions. Members of the Scientific Committee graded the quality of the supporting evidence and the consensus recommendations using the GRADE system. Conclusions: Evidence-based approach consensus recommendations address important clinical issues regarding multidisciplinary management of acromegaly-related cardiovascular, endocrine, metabolic, and oncologic comorbidities, sleep apnea, and bone and joint disorders and their sequelae, as well as their effects on quality of life and mortality.

Original language	English (US)
Pages (from-to)	E937-E946
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	105
Issue number	4
DOIs	https://doi.org/10.1210/clinem/dgz096
State	Published - Apr 1 2020

Keywords

Acromegaly
Comorbidities
Consensus
Diagnosis
Treatment

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/clinem/dgz096

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Giustina, A., Barkan, A., Beckers, A., Biermasz, N., Biller, B. M. K., Boguszewski, C., Bolanowski, M., Bonert, V., Bronstein, M. D., Casanueva, F. F., Clemmons, D., Colao, A., Ferone, D., Fleseriu, M., Frara, S., Gadelha, M. R., Ghigo, E., Gurnell, M., Heaney, A. P., ... Melmed, S. (2020). A consensus on the diagnosis and treatment of acromegaly comorbidities: An update. Journal of Clinical Endocrinology and Metabolism, 105(4), E937-E946. https://doi.org/10.1210/clinem/dgz096

Giustina, A, Barkan, A, Beckers, A, Biermasz, N, Biller, BMK, Boguszewski, C, Bolanowski, M, Bonert, V, Bronstein, MD, Casanueva, FF, Clemmons, D, Colao, A, Ferone, D, Fleseriu, M, Frara, S, Gadelha, MR, Ghigo, E, Gurnell, M, Heaney, AP, Ho, K, Ioachimescu, A, Katznelson, L, Kelestimur, F, Kopchick, J, Krsek, M, Lamberts, S, Losa, M, Luger, A, Maffei, P, Marazuela, M, Mazziotti, G, Mercado, M, Mortini, P, Neggers, S, Pereira, AM, Petersenn, S, Puig-Domingo, M, Salvatori, R, Shimon, I, Strasburger, C, Tsagarakis, S, van der Lely, AJ, Wass, J, Zatelli, MC & Melmed, S 2020, 'A consensus on the diagnosis and treatment of acromegaly comorbidities: An update', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 4, pp. E937-E946. https://doi.org/10.1210/clinem/dgz096

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title = "A consensus on the diagnosis and treatment of acromegaly comorbidities: An update",

abstract = "Objective: The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013. Participants: The Consensus Group, convened by 11 Steering Committee members, consisted of 45 experts in the medical and surgical management of acromegaly. The authors received no corporate funding or remuneration. Evidence: This evidence-based consensus was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence following critical discussion of the current literature on the diagnosis and treatment of acromegaly comorbidities. Consensus Process: Acromegaly Consensus Group participants conducted comprehensive literature searches for English-language papers on selected topics, reviewed brief presentations on each topic, and discussed current practice and recommendations in breakout groups. Consensus recommendations were developed based on all presentations and discussions. Members of the Scientific Committee graded the quality of the supporting evidence and the consensus recommendations using the GRADE system. Conclusions: Evidence-based approach consensus recommendations address important clinical issues regarding multidisciplinary management of acromegaly-related cardiovascular, endocrine, metabolic, and oncologic comorbidities, sleep apnea, and bone and joint disorders and their sequelae, as well as their effects on quality of life and mortality.",

keywords = "Acromegaly, Comorbidities, Consensus, Diagnosis, Treatment",

author = "Andrea Giustina and Ariel Barkan and Albert Beckers and Nienke Biermasz and Biller, {Beverly M.K.} and Cesar Boguszewski and Marek Bolanowski and Vivien Bonert and Bronstein, {Marcello D.} and Casanueva, {Felipe F.} and David Clemmons and Annamaria Colao and Diego Ferone and Maria Fleseriu and Stefano Frara and Gadelha, {Monica R.} and Ezio Ghigo and Mark Gurnell and Heaney, {Anthony P.} and Ken Ho and Adriana Ioachimescu and Laurence Katznelson and Fahrettin Kelestimur and John Kopchick and Michal Krsek and Steven Lamberts and Marco Losa and Anton Luger and Pietro Maffei and Monica Marazuela and Gherardo Mazziotti and Moises Mercado and Pietro Mortini and Sebastian Neggers and Pereira, {Alberto M.} and Stephan Petersenn and Manel Puig-Domingo and Roberto Salvatori and Ilan Shimon and Christian Strasburger and Stylianos Tsagarakis and {van der Lely}, {A. J.} and John Wass and Zatelli, {Maria Chiara} and Shlomo Melmed",

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T1 - A consensus on the diagnosis and treatment of acromegaly comorbidities

T2 - An update

AU - Giustina, Andrea

AU - Barkan, Ariel

AU - Beckers, Albert

AU - Biermasz, Nienke

AU - Biller, Beverly M.K.

AU - Boguszewski, Cesar

AU - Bolanowski, Marek

AU - Bonert, Vivien

AU - Bronstein, Marcello D.

AU - Casanueva, Felipe F.

AU - Clemmons, David

AU - Colao, Annamaria

AU - Ferone, Diego

AU - Fleseriu, Maria

AU - Frara, Stefano

AU - Gadelha, Monica R.

AU - Ghigo, Ezio

AU - Gurnell, Mark

AU - Heaney, Anthony P.

AU - Ho, Ken

AU - Ioachimescu, Adriana

AU - Katznelson, Laurence

AU - Kelestimur, Fahrettin

AU - Kopchick, John

AU - Krsek, Michal

AU - Lamberts, Steven

AU - Losa, Marco

AU - Luger, Anton

AU - Maffei, Pietro

AU - Marazuela, Monica

AU - Mazziotti, Gherardo

AU - Mercado, Moises

AU - Mortini, Pietro

AU - Neggers, Sebastian

AU - Pereira, Alberto M.

AU - Petersenn, Stephan

AU - Puig-Domingo, Manel

AU - Salvatori, Roberto

AU - Shimon, Ilan

AU - Strasburger, Christian

AU - Tsagarakis, Stylianos

AU - van der Lely, A. J.

AU - Wass, John

AU - Zatelli, Maria Chiara

AU - Melmed, Shlomo

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Objective: The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013. Participants: The Consensus Group, convened by 11 Steering Committee members, consisted of 45 experts in the medical and surgical management of acromegaly. The authors received no corporate funding or remuneration. Evidence: This evidence-based consensus was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence following critical discussion of the current literature on the diagnosis and treatment of acromegaly comorbidities. Consensus Process: Acromegaly Consensus Group participants conducted comprehensive literature searches for English-language papers on selected topics, reviewed brief presentations on each topic, and discussed current practice and recommendations in breakout groups. Consensus recommendations were developed based on all presentations and discussions. Members of the Scientific Committee graded the quality of the supporting evidence and the consensus recommendations using the GRADE system. Conclusions: Evidence-based approach consensus recommendations address important clinical issues regarding multidisciplinary management of acromegaly-related cardiovascular, endocrine, metabolic, and oncologic comorbidities, sleep apnea, and bone and joint disorders and their sequelae, as well as their effects on quality of life and mortality.

AB - Objective: The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013. Participants: The Consensus Group, convened by 11 Steering Committee members, consisted of 45 experts in the medical and surgical management of acromegaly. The authors received no corporate funding or remuneration. Evidence: This evidence-based consensus was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence following critical discussion of the current literature on the diagnosis and treatment of acromegaly comorbidities. Consensus Process: Acromegaly Consensus Group participants conducted comprehensive literature searches for English-language papers on selected topics, reviewed brief presentations on each topic, and discussed current practice and recommendations in breakout groups. Consensus recommendations were developed based on all presentations and discussions. Members of the Scientific Committee graded the quality of the supporting evidence and the consensus recommendations using the GRADE system. Conclusions: Evidence-based approach consensus recommendations address important clinical issues regarding multidisciplinary management of acromegaly-related cardiovascular, endocrine, metabolic, and oncologic comorbidities, sleep apnea, and bone and joint disorders and their sequelae, as well as their effects on quality of life and mortality.

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KW - Comorbidities

KW - Consensus

KW - Diagnosis

KW - Treatment

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A consensus on the diagnosis and treatment of acromegaly comorbidities: An update

Abstract

Keywords

ASJC Scopus subject areas

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