TY - JOUR
T1 - A computational multiresolution BOLD fMRI model
AU - Chen, Zikuan
AU - Calhoun, Vince
N1 - Funding Information:
Manuscript received February 19, 2011; revised May 6, 2011; accepted May 29, 2011. Date of publication June 7, 2011; date of current version September 21, 2011. This work was supported in part by the National Science Foundation under Grant 0715022 and Grant 0840895 and in part by the Mind Research Network under Internal Grant 6003-154 of DE-FG02-08ER64581. Asterisk indicates corresponding author. *Z. Chen is with the Mind Research Network, Albuquerque, NM 87106 USA (e-mail: zchen@mrn.org).
PY - 2011/10
Y1 - 2011/10
N2 - Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is a widely used method for brain mapping. BOLD fMRI signal detection is based on an intravoxel dephasing mechanism. This model involves bulk nuclear spin precession in a BOLD-induced inhomogeneous magnetic field within a millimeter-resolution voxel, that is, BOLD signal formation spans a huge spatial scale range from Angstrom to millimeter. In this letter, we present a computational model for multiresolution BOLD fMRI simulation, which consists of partitioning the nuclear spin pool into spin packets at a mesoscopic scale (10 -6 m), and calculating multiresolution voxel signals by grouping spin packets at a macroscopic scale range (10 -5to 10 -3 m). Under a small-angle approximation, we find that the BOLD signal intensity is related to its phase counterpart (or BOLD fieldmap) across two spatial resolution levels.
AB - Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is a widely used method for brain mapping. BOLD fMRI signal detection is based on an intravoxel dephasing mechanism. This model involves bulk nuclear spin precession in a BOLD-induced inhomogeneous magnetic field within a millimeter-resolution voxel, that is, BOLD signal formation spans a huge spatial scale range from Angstrom to millimeter. In this letter, we present a computational model for multiresolution BOLD fMRI simulation, which consists of partitioning the nuclear spin pool into spin packets at a mesoscopic scale (10 -6 m), and calculating multiresolution voxel signals by grouping spin packets at a macroscopic scale range (10 -5to 10 -3 m). Under a small-angle approximation, we find that the BOLD signal intensity is related to its phase counterpart (or BOLD fieldmap) across two spatial resolution levels.
KW - Intravoxel dephasing
KW - multiresolution blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI)
KW - phasor
KW - small-angle approximation
KW - spin packet
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U2 - 10.1109/TBME.2011.2158823
DO - 10.1109/TBME.2011.2158823
M3 - Article
C2 - 21652281
AN - SCOPUS:80053165919
SN - 0018-9294
VL - 58
SP - 2995
EP - 2999
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 10 PART 2
M1 - 5784323
ER -