A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection

S. Anand Narayanan; David A. Jamison; Joseph W. Guarnieri; Victoria Zaksas; Michael Topper; Andrew P. Koutnik; Jiwoon Park; Kevin B. Clark; Francisco J. Enguita; Ana Lúcia Leitão; Saswati Das; Pedro M. Moraes-Vieira; Diego Galeano; Christopher E. Mason; Nídia S. Trovão; Robert E. Schwartz; Jonathan C. Schisler; Jordana G.A. Coelho-dos-Reis; Eve Syrkin Wurtele; Afshin Beheshti

doi:10.1038/s41431-023-01462-1

A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection

S. Anand Narayanan, David A. Jamison, Joseph W. Guarnieri, Victoria Zaksas, Michael Topper, Andrew P. Koutnik, Jiwoon Park, Kevin B. Clark, Francisco J. Enguita, Ana Lúcia Leitão, Saswati Das, Pedro M. Moraes-Vieira, Diego Galeano, Christopher E. Mason, Nídia S. Trovão, Robert E. Schwartz, Jonathan C. Schisler, Jordana G.A. Coelho-dos-Reis, Eve Syrkin Wurtele, Afshin Beheshti

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

COVID-19, the disease caused by SARS-CoV-2, has caused significant morbidity and mortality worldwide. The betacoronavirus continues to evolve with global health implications as we race to learn more to curb its transmission, evolution, and sequelae. The focus of this review, the second of a three-part series, is on the biological effects of the SARS-CoV-2 virus on post-acute disease in the context of tissue and organ adaptations and damage. We highlight the current knowledge and describe how virological, animal, and clinical studies have shed light on the mechanisms driving the varied clinical diagnoses and observations of COVID-19 patients. Moreover, we describe how investigations into SARS-CoV-2 effects have informed the understanding of viral pathogenesis and provide innovative pathways for future research on the mechanisms of viral diseases.

Original language	English (US)
Pages (from-to)	10-20
Number of pages	11
Journal	European Journal of Human Genetics
Volume	32
Issue number	1
DOIs	https://doi.org/10.1038/s41431-023-01462-1
State	Published - Jan 2024

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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Narayanan, S. A., Jamison, D. A., Guarnieri, J. W., Zaksas, V., Topper, M., Koutnik, A. P., Park, J., Clark, K. B., Enguita, F. J., Leitão, A. L., Das, S., Moraes-Vieira, P. M., Galeano, D., Mason, C. E., Trovão, N. S., Schwartz, R. E., Schisler, J. C., Coelho-dos-Reis, J. G. A., Wurtele, E. S., & Beheshti, A. (2024). A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection. European Journal of Human Genetics, 32(1), 10-20. https://doi.org/10.1038/s41431-023-01462-1

Narayanan, SA, Jamison, DA, Guarnieri, JW, Zaksas, V, Topper, M, Koutnik, AP, Park, J, Clark, KB, Enguita, FJ, Leitão, AL, Das, S, Moraes-Vieira, PM, Galeano, D, Mason, CE, Trovão, NS, Schwartz, RE, Schisler, JC, Coelho-dos-Reis, JGA, Wurtele, ES & Beheshti, A 2024, 'A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection', European Journal of Human Genetics, vol. 32, no. 1, pp. 10-20. https://doi.org/10.1038/s41431-023-01462-1

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abstract = "COVID-19, the disease caused by SARS-CoV-2, has caused significant morbidity and mortality worldwide. The betacoronavirus continues to evolve with global health implications as we race to learn more to curb its transmission, evolution, and sequelae. The focus of this review, the second of a three-part series, is on the biological effects of the SARS-CoV-2 virus on post-acute disease in the context of tissue and organ adaptations and damage. We highlight the current knowledge and describe how virological, animal, and clinical studies have shed light on the mechanisms driving the varied clinical diagnoses and observations of COVID-19 patients. Moreover, we describe how investigations into SARS-CoV-2 effects have informed the understanding of viral pathogenesis and provide innovative pathways for future research on the mechanisms of viral diseases.",

author = "Narayanan, {S. Anand} and Jamison, {David A.} and Guarnieri, {Joseph W.} and Victoria Zaksas and Michael Topper and Koutnik, {Andrew P.} and Jiwoon Park and Clark, {Kevin B.} and Enguita, {Francisco J.} and Leit{\~a}o, {Ana L{\'u}cia} and Saswati Das and Moraes-Vieira, {Pedro M.} and Diego Galeano and Mason, {Christopher E.} and Trov{\~a}o, {N{\'i}dia S.} and Schwartz, {Robert E.} and Schisler, {Jonathan C.} and Coelho-dos-Reis, {Jordana G.A.} and Wurtele, {Eve Syrkin} and Afshin Beheshti",

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AU - Leitão, Ana Lúcia

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AU - Moraes-Vieira, Pedro M.

AU - Galeano, Diego

AU - Mason, Christopher E.

AU - Trovão, Nídia S.

AU - Schwartz, Robert E.

AU - Schisler, Jonathan C.

AU - Coelho-dos-Reis, Jordana G.A.

AU - Wurtele, Eve Syrkin

AU - Beheshti, Afshin

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AB - COVID-19, the disease caused by SARS-CoV-2, has caused significant morbidity and mortality worldwide. The betacoronavirus continues to evolve with global health implications as we race to learn more to curb its transmission, evolution, and sequelae. The focus of this review, the second of a three-part series, is on the biological effects of the SARS-CoV-2 virus on post-acute disease in the context of tissue and organ adaptations and damage. We highlight the current knowledge and describe how virological, animal, and clinical studies have shed light on the mechanisms driving the varied clinical diagnoses and observations of COVID-19 patients. Moreover, we describe how investigations into SARS-CoV-2 effects have informed the understanding of viral pathogenesis and provide innovative pathways for future research on the mechanisms of viral diseases.

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A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection

Abstract

ASJC Scopus subject areas

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