A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

David A. Jamison; S. Anand Narayanan; Nídia S. Trovão; Joseph W. Guarnieri; Michael J. Topper; Pedro M. Moraes-Vieira; Viktorija Zaksas; Keshav K. Singh; Eve Syrkin Wurtele; Afshin Beheshti

doi:10.1038/s41431-022-01108-8

A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

David A. Jamison
, S. Anand Narayanan
, Nídia S. Trovão
, Joseph W. Guarnieri
, Michael J. Topper
, Pedro M. Moraes-Vieira
, Viktorija Zaksas
, Keshav K. Singh
, Eve Syrkin Wurtele
, Afshin Beheshti

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus’ mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.

Original language	English (US)
Pages (from-to)	889-898
Number of pages	10
Journal	European Journal of Human Genetics
Volume	30
Issue number	8
DOIs	https://doi.org/10.1038/s41431-022-01108-8
State	Published - Aug 2022

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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10.1038/s41431-022-01108-8

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Jamison, D. A., Anand Narayanan, S., Trovão, N. S., Guarnieri, J. W., Topper, M. J., Moraes-Vieira, P. M., Zaksas, V., Singh, K. K., Wurtele, E. S., & Beheshti, A. (2022). A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection. European Journal of Human Genetics, 30(8), 889-898. https://doi.org/10.1038/s41431-022-01108-8

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title = "A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection",

abstract = "COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus{\textquoteright} mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.",

author = "Jamison, \{David A.\} and \{Anand Narayanan\}, S. and Trov{\~a}o, \{N{\'i}dia S.\} and Guarnieri, \{Joseph W.\} and Topper, \{Michael J.\} and Moraes-Vieira, \{Pedro M.\} and Viktorija Zaksas and Singh, \{Keshav K.\} and Wurtele, \{Eve Syrkin\} and Afshin Beheshti",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = aug,

doi = "10.1038/s41431-022-01108-8",

language = "English (US)",

volume = "30",

pages = "889--898",

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AU - Trovão, Nídia S.

AU - Guarnieri, Joseph W.

AU - Topper, Michael J.

AU - Moraes-Vieira, Pedro M.

AU - Zaksas, Viktorija

AU - Singh, Keshav K.

AU - Wurtele, Eve Syrkin

AU - Beheshti, Afshin

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AB - COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus’ mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.

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A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

Abstract

ASJC Scopus subject areas

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